Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2

被引：434

作者：

Ebinger, Joseph E. ^{[1
]}

Fert-Bober, Justyna ^{[1
,2
]}

Printsev, Ignat ^{[3
,4
]}

Wu, Min ^{[1
]}

Sun, Nancy ^{[1
]}

Prostko, John C. ^{[5
]}

Frias, Edwin C. ^{[5
]}

Stewart, James L. ^{[5
]}

Van Eyk, Jennifer E. ^{[1
,2
]}

Braun, Jonathan G. ^{[3
,4
,6
]}

Cheng, Susan ^{[1
]}

Sobhani, Kimia ^{[6
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Cardiol, Smidt Heart Inst, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Biomed Sci, Adv Clin Biosyst Inst, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, F Widjaja Fdn Inflammatory Bowel, Los Angeles, CA 90048 USA

[4] Cedars Sinai Med Ctr, Immunobiol Res Inst, Los Angeles, CA 90048 USA

[5] Abbott Diagnost, Appl Res & Technol, Abbott Pk, IL USA

[6] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

来源：

NATURE MEDICINE | 2021年 / 27卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/s41591-021-01325-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus-specific antibody levels after a single dose of the BNT162b2 vaccine in individuals previously infected with SARS-CoV-2 are similar to levels after two doses of the vaccine in infection-naive individuals. In a cohort of BNT162b2 (Pfizer-BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection (n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection (n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.

引用

页码：981 / +

页数：12

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