Circular RNAs: Biogenesis, Mechanism, and Function in Human Cancers

被引：191

作者：

Zhao, Xing ^{[1
,2
]}

Cai, Yujie ^{[1
]}

Xu, Jianzhen ^{[1
]}

机构：

[1] Shantou Univ, Med Coll SUMC, Dept Bioinformat, Computat Syst Biol Lab, 22 Xinling Rd, Shantou 515041, Peoples R China

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9700 RB Groningen, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 16期

基金：

中国国家自然科学基金;

关键词：

circRNAs; carcinogenesis; biogenesis; RNA-binding protein; flanking introns; genomic alternation; LANDSCAPE; CIRCHIPK3; PROTEINS; MICRORNA; ABUNDANT; REVEALS; MAP;

D O I：

10.3390/ijms20163926

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. In this review, we will first provide an introduction of circRNAs biogenesis, especially the regulation of circRNA by RNA-binding proteins, then we will focus on the recent findings of circRNA molecular mechanisms and functions in cancer development. Finally, some open questions are also discussed.

引用

页数：13

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