Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)-H Amination

被引：40

作者：

Roy, Satyajit ^{[1
,2
]}

Das, Sandip Kumar ^{[1
]}

Khatua, Hillol ^{[1
]}

Das, Subrata ^{[1
]}

Singh, Krishna Nand ^{[2
]}

Chattopadhyay, Buddhadeb ^{[1
]}

机构：

[1] Ctr Biomed Res CBMR, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow 226014, UP, India

[2] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 16期

关键词：

homogeneous catalysis; denitrogenative annulation; Fe-nitrene; metalloradicals; nitrogen heterocycles;

D O I：

10.1002/anie.202014950

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp(3))-H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.

引用

收藏

页码：8772 / 8780

页数：9

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