Muscimol changes hypoxia-induced impairment of behavior in rats

被引:0
作者
Oksztel, R [1 ]
Car, H [1 ]
Wisniewski, K [1 ]
机构
[1] Med Acad Bialystok, Dept Pharmacol, PL-15222 Bialystok, Poland
来源
POLISH JOURNAL OF PHARMACOLOGY | 2002年 / 54卷 / 05期
关键词
muscimol; hypoxia; behavior rats;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Muscimol, a selective agonist of GABA-A receptors, causes changes in behavioral activity. Hypoxia interferes with the GABAergic system and with the functions of GABA-A receptors. We used muscimol in Wistar rats to estimate its influence on locomotor activity in the open field test as well as on the processes of consolidation and retrieval, evaluated in the test of passive conditioned reflexes. Anxiolytic activity was examined in the elevated "plus" maze in physiological state and after hypoxia-induced amnesia. Following intraperitoneal administration of muscimol (1 mg/kg, ip), the animals showed a decrease in motility, in retrieval of skill reflexes and in a number of entries into open and closed arms in the elevated plus "maze". In animals exposed to hypoxia, we observed reduced motility in the open field, inhibition of retrieval and consolidation of passive conditioned reflexes, shortened time of sojourn in open arms and decreased number of entries into open and closed arms. In the group of animals which underwent hypoxia and then received muscimol, we observed no effect of hypoxia on muscimol activity in the open field test, except rearing when muscimol action was significantly reduced. Muscimol improved consolidation but not retrieval in comparison with the hypoxic saline-treated group of rats. In the elevated "plus" maze test, treatment of rats with muscimol after hypoxia significantly prolonged the time spent in open arms and increased the number of entries into open arms, while shortened the time spent in closed arms. In conclusion, muscimol in hypoxia-exposed group of rats exerted beneficial effect on consolidation in passive avoidance situation and exerted anxiolytic activity. Changes in the activity of muscimol under hypoxia may have significant clinical implications.
引用
收藏
页码:423 / 431
页数:9
相关论文
共 50 条
[1]   Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats [J].
Car, H ;
Oksztel, R ;
Nadlewska, A ;
Wisniewski, K .
PHARMACOLOGICAL RESEARCH, 2001, 44 (04) :329-335
[2]   Role of nitric oxide in hypoxia-induced changes in newborn rats [J].
Kiliç, I ;
Kiliç, BA ;
Güven, C ;
Demirpençe, E ;
Aksit, MA .
BIOLOGY OF THE NEONATE, 2000, 78 (03) :191-197
[3]   Hypoxia-Induced Kidney Injury in Newborn Rats [J].
Chu, Yi-Ting ;
Chen, Bo-Hau ;
Chen, Hsin-Hung ;
Lee, Jui-Chen ;
Kuo, Tzu-Jiun ;
Chiu, Hsiang-Chin ;
Lu, Wen-Hsien .
TOXICS, 2023, 11 (03)
[4]   Hypoxia-induced Stress Proteins in Heart of Rats [J].
任惠民 ;
周兆年 .
ChineseScienceBulletin, 1993, (21) :1811-1815
[5]   HYPOXIA-INDUCED STRESS PROTEINS IN HEART OF RATS [J].
REN, HM ;
ZHOU, ZN .
CHINESE SCIENCE BULLETIN, 1993, 38 (21) :1811-1815
[6]   HYPOXIA-INDUCED ELECTRICAL CHANGES IN STRIATAL NEURONS [J].
CALABRESI, P ;
PISANI, A ;
MERCURI, NB ;
BERNARDI, G .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (06) :1141-1145
[7]   Hypoxia-induced changes in neuronal network properties [J].
Peña, F ;
Ramirez, AM .
MOLECULAR NEUROBIOLOGY, 2005, 32 (03) :251-283
[8]   Hypoxia-induced changes in neuronal network properties [J].
Fernando Peña ;
Jan-Marino Ramirez .
Molecular Neurobiology, 2005, 32 :251-283
[9]   The role of mTOR signalling pathway in hypoxia-induced cognitive impairment [J].
Qaid, Entesar Yaseen Abdo ;
Zulkipli, Ninie Nadia ;
Zakaria, Rahimah ;
Ahmad, Asma Hayati ;
Othman, Zahiruddin ;
Muthuraju, Sangu ;
Sasongko, Teguh Haryo .
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2021, 131 (05) :482-488
[10]   Time course of hypoxia-induced lung injury in rats [J].
Rassler, Beate ;
Marx, Grit ;
Reissig, Christian ;
Rohling, Marc A. ;
Tannapfel, Andrea ;
Wenger, Roland H. ;
Zimmer, Heinz-Gerd .
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2007, 159 (01) :45-54