A simplified green chemistry approach to the Biginelli reaction using 'Grindstone Chemistry'

被引：175

作者：

Bose, AK ^{[1
]}

Pednekar, S

Ganguly, SN

Chakraborty, G

Manhas, MS

机构：

[1] Stevens Inst Technol, Dept Chem & Biol Chem, George Barasch Bioorgan Res Lab, Hoboken, NJ 07030 USA

[2] Montclair State Univ, Dept Chem & Biochem, Montclair, NJ 07043 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 45期

关键词：

tetrahydropyrimidinone; reaction by grinding; solvent-free reaction; p-TSA as an acid catalyst;

D O I：

10.1016/j.tetlet.2004.09.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Grindstone Chemistry-a greatly evolved version of Toda's method of grinding solids together for solvent-free chemical reactions-has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones. (C) 2004 Published by Elsevier Ltd.

引用

页码：8351 / 8353

页数：3

共 10 条

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