COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

被引:1
作者
Benbassat, Jochanan [1 ,5 ]
Froom, Paul [2 ,3 ]
Shimoni, Zvi [4 ]
机构
[1] Hadassah Univ Hosp Jerusalem, Dept Med, Jerusalem, Israel
[2] Laniado Hosp, Sanz Med Ctr, Clin Util Dept, Netanya, Israel
[3] Tel Aviv Univ, Sch Publ Hlth, Tel Aviv, Israel
[4] Laniado Hosp, Sanz Med Ctr, Netanya, Israel
[5] POB 3894, IL-91037 Jerusalem, Israel
关键词
COVID-19; vaccination; Mortality; Efficacy of vaccine; Healthy adherer effect; Retrospective cohort studies; Israel; UNITED-STATES; ADHERENCE; RISK;
D O I
10.1016/j.ypmed.2022.107326
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65-2.44) (unadjusted) and 1.61 (1.29-2.03) after adjustment for the independent variables. This "healthy adherer effect" may confound observational assessments of the clinical efficacy of COVID-19 vaccines.
引用
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页数:3
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共 13 条
[1]  
Andrews N, 2022, NEW ENGL J MED, V386, P1532, DOI [10.1056/NEJMoa2119451, 10.1016/S1473-3099(22)00309-7]
[2]   BNT162b2 Vaccine Booster and Mortality Due to Covid-19 [J].
Arbel, Ronen ;
Hammerman, Ariel ;
Sergienko, Ruslan ;
Friger, Michael ;
Peretz, Alon ;
Netzer, Doron ;
Yaron, Shlomit .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (26) :2413-2420
[3]   Adverse events following mRNA SARS-CoV-2 vaccination among US nursing home residents [J].
Bardenheier, Barbara H. ;
Gravenstein, Stefan ;
Blackman, Carolyn ;
Gutman, Roee ;
Sarkar, Indra Neil ;
Feifer, Richard A. ;
White, Elizabeth M. ;
McConeghy, Kevin ;
Nanda, Aman ;
Mor, Vincent .
VACCINE, 2021, 39 (29) :3844-3851
[4]  
CANNER PL, 1980, NEW ENGL J MED, V303, P1038
[5]   Current COVID-19 vaccine trials in high-income countries: are placebo-controlled trials ethical? [J].
Dal-Re, Rafael ;
Caplan, Arthur L. .
CLINICAL MICROBIOLOGY AND INFECTION, 2021, 27 (11) :1565-1567
[6]   Covid-19 Vaccine Effectiveness and the Test-Negative Design [J].
Dean, Natalie E. ;
Hogan, Joseph W. ;
Schnitzer, Mireille E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (15) :1431-1433
[7]   Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors [J].
Jackson, LA ;
Nelson, JC ;
Benson, P ;
Neuzil, KM ;
Reid, RJ ;
Psaty, BM ;
Heckbert, SR ;
Larson, EB ;
Weiss, NS .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (02) :345-352
[8]   Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting [J].
Magen, Ori ;
Waxman, Jacob G. ;
Makov-Assif, Maya ;
Vered, Roni ;
Dicker, Dror ;
Hernan, Miguel A. ;
Lipsitch, Marc ;
Reis, Ben Y. ;
Balicer, Ran D. ;
Dagan, Noa .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (17) :1603-1614
[9]   Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [J].
Pormohammad, Ali ;
Zarei, Mohammad ;
Ghorbani, Saied ;
Mohammadi, Mehdi ;
Razizadeh, Mohammad Hossein ;
Turner, Diana L. ;
Turner, Raymond J. .
VACCINES, 2021, 9 (05)
[10]   Covid-19 Vaccine Effectiveness in New York State [J].
Rosenberg, Eli S. ;
Dorabawila, Vajeera ;
Easton, Delia ;
Bauer, Ursula E. ;
Kumar, Jessica ;
Hoen, Rebecca ;
Hoefer, Dina ;
Wu, Meng ;
Lutterloh, Emily ;
Conroy, Mary Beth ;
Greene, Danielle ;
Zucker, Howard A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (02) :116-127