Effects of prenatal exposure to cigarette smoke on biochemical parameters of the blood of adult rat offspring

被引：0

作者：

Shakhanbeh, Jumah ^{[1
]}

Al-Mustafa, Ahmed ^{[1
]}

Rawashdeh, Rami ^{[1
]}

机构：

[1] Mutah Univ, Fac Sci, Dept Biol, POB 7, Al Karak, Jordan

来源：

BIOSCIENCE RESEARCH | 2020年 / 17卷 / 04期

关键词：

Pregnant rats; cigarette smoke; blood; maternal smoking; biochemical parameters; adult rat offspring; MATERNAL TOBACCO SMOKING; IN-UTERO EXPOSURE; LOW-BIRTH-WEIGHT; NICOTINE-EXPOSURE; FETAL EXPOSURE; GLUCOSE-HOMEOSTASIS; PREGNANCY; COTININE; PRESSURE; SUSCEPTIBILITY;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prenatal cigarette smoke (CS) exposure during pregnancy is known to be associated with many severe prenatal and postnatal developmental abnormalities. The present study investigates serum biochemical parameters of adult rat offspring exposed prenatally to CS. Female white albino rats were exposed to CS during pregnancy 3 times/day (each 15 minutes) from gestational day 0 to parturition. Serum biochemical parameters were measured in adult male and female rat offspring (9-10 weeks in age) exposed prenatally to CS. Maternal CS exposure during gestation had no significant (P > 0.1) effect on serum biochemical parameters, including glucose, total proteins, albumins, globulins, albumins/globulins ratio, cholesterol, triglycerides, high density lipoproteins (HDL), low density lipoproteins (LDL), creatinine, bilirubin, urea, uric acid, alanine aminotransferase (ALT), alkaline phosphatase (ALP) in the blood of adult male and female rat offspring. However, prenatal CS exposure significantly ( P < 0.05) decreases serum aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) in the blood of adult male and female rat offspring. Results demonstrated that CS exposure during gestation significantly decreases serum AST and GGT in the blood of adult male and female rat offspring.

引用

页码：2856 / 2862

页数：7

共 67 条

[41] Locomotor behavioral effects of prenatal and postnatal nicotine exposure in rat offspring [J].

Newman, MB ;

Shytle, RD ;

Sanberg, PR .

BEHAVIOURAL PHARMACOLOGY, 1999, 10 (6-7) :699-706

[42] The effects of prenatal exposure of mice to cigarette smoke on offspring immune parameters [J].

Ng, Sheung P. ;

Zelikoff, Judith T. .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2008, 71 (07) :445-453

[43] Prenatal Exposure to Cigarette Smoke Induces Diet- and Sex-Dependent Dyslipidemia and Weight Gain in Adult Murine Offspring [J].

Ng, Sheung P. ;

Conklin, Daniel J. ;

Bhatnagar, Aruni ;

Bolanowski, Duane D. ;

Lyon, Jessica ;

Zelikoff, Judith T. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2009, 117 (07) :1042-1048

[44] Effects of prenatal exposure to cigarette smoke on offspring tumor susceptibility and associated immune mechanisms [J].

Ng, SP ;

Silverstone, AE ;

Lai, ZW ;

Zelikoff, JT .

TOXICOLOGICAL SCIENCES, 2006, 89 (01) :135-144

[45] Associations of maternal prenatal smoking with child adiposity and blood pressure [J].

Oken, E ;

Huh, SY ;

Taveras, EM ;

Rich-Edwards, JW ;

Gillman, MW .

OBESITY RESEARCH, 2005, 13 (11) :2021-2028

[46] Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats:: A case of gene-environment interaction [J].

Pausová, Z ;

Paus, T ;

Sedová, L ;

Bérubé, J .

KIDNEY INTERNATIONAL, 2003, 64 (03) :829-835

[47] Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia [J].

Pendlebury, Jonathan D. ;

Yusuf, Kamran ;

Bano, Shehr ;

Lumb, Kathleen J. ;

Schneider, Jennifer M. ;

Hasan, Shabih U. .

PEDIATRIC PULMONOLOGY, 2012, 47 (05) :487-497

[48] Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage [J].

Perera, FP ;

Tang, DL ;

Tu, YH ;

Cruz, LA ;

Borjas, M ;

Bernert, T ;

Whyatt, RM .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (10) :1133-1136

[49] Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy [J].

Pichini, S ;

Basagaña, X ;

Pacifici, R ;

Garcia, O ;

Puig, C ;

Vall, O ;

Harris, J ;

Zuccaro, P ;

Segura, J ;

Sunyer, J .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (11) :1079-1083

[50] Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex [J].

Roy, TS ;

Seidler, FJ ;

Slotkin, TA .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (01) :124-133

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