Accumulation of imidazolone, pentosidine and Nε-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain

被引:44
作者
Jono, T
Kimura, T
Takamatsu, J
Nagai, R
Miyazaki, K
Yuzuriha, T
Kitamura, T
Horiuchi, S
机构
[1] Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 8608556, Japan
[2] Kumamoto Univ, Sch Med, Dept Psychiat, Kumamoto 8608556, Japan
[3] Kikuchi Natl Hosp, Div Clin Res, Kumamoto, Japan
[4] Hizen Mental Hosp, Ctr Emot & Behav Disorders, Saga, Japan
关键词
advanced glycation end products; aging; brain; imidazolone; N-epsilon-(carboxymethyl)lysine; pentosidine;
D O I
10.1046/j.1320-5463.2002.01390.x
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Previous studies from our laboratory demonstrated that N-epsilon-(carboxymethyl)lysine (CML), one of the major advanced glycation end products (AGE), was accumulated in human pyramidal neurons in the hippocampus in an age-dependent manner. This suggests a potential link between AGE-accumulation and the aging process in neurons. The purpose of the present study was to examine whether this notion could be extended to other AGE structures, such as imidazolone and pentosidine. This was done using 19 human brains that were not affected by dementia. The immunohistochemical survey on distribution in brain tissues of imidazolone and pentosidine was carried out with monoclonal antibodies specific for imidazolone and pentosidine. A parallel control experiment was carried out with anti-CML antibody. The results showed that pentosidine and imidazolone were localized in neurons in different areas of human brain tissue, especially in neurons of CA4 in the hippocampus. The characteristic distribution of pentosidine and imidazolone is very similar to that of CML. Furthermore, when the accumulation of these AGE structures was compared with the age of individual brains it was found that accumulation of imidazolone, pentosidine and CML in the CA4 region increased with age. These findings taken together support the notion that the accumulation of AGE structures in the CA4 region might be closely related to the aging process in neurons.
引用
收藏
页码:563 / 571
页数:9
相关论文
共 50 条
[31]   IMMUNOCHEMICAL DETECTION OF ADVANCED GLYCATION END-PRODUCTS IN RENAL-CORTEX FROM STZ-INDUCED DIABETIC RAT [J].
MITSUHASHI, T ;
NAKAYAMA, H ;
ITOH, T ;
KUWAJIMA, S ;
AOKI, S ;
ATSUMI, T ;
KOIKE, T .
DIABETES, 1993, 42 (06) :826-832
[32]   BETA(2)-MICROGLOBULIN MODIFIED WITH ADVANCED GLYCATION END-PRODUCTS IS A MAJOR COMPONENT OF HEMODIALYSIS-ASSOCIATED AMYLOIDOSIS [J].
MIYATA, T ;
ODA, O ;
INAGI, R ;
IIDA, Y ;
ARAKI, N ;
YAMADA, N ;
HORIUCHI, S ;
TANIGUCHI, N ;
MAEDA, K ;
KINOSHITA, T .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (03) :1243-1252
[33]   Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype [J].
Montine, KS ;
Reich, E ;
Neely, MD ;
Sidell, KR ;
Olson, SJ ;
Markesbery, WR ;
Montine, TJ .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (05) :415-425
[34]   Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide [J].
Munch, G ;
Mayer, S ;
Michaelis, J ;
Hipkiss, AR ;
Riederer, P ;
Muller, R ;
Neumann, A ;
Schinzel, R ;
Cunningham, AM .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1997, 1360 (01) :17-29
[35]  
NAKAMURA Y, 1993, AM J PATHOL, V143, P1649
[36]   IMMUNOCHEMICAL DETECTION OF ADVANCED GLYCATION END-PRODUCTS IN LENS CRYSTALLINS FROM STREPTOZOCIN-INDUCED DIABETIC RAT [J].
NAKAYAMA, H ;
MITSUHASHI, T ;
KUWAJIMA, S ;
AOKI, S ;
KURODA, Y ;
ITOH, T ;
NAKAGAWA, S .
DIABETES, 1993, 42 (02) :345-350
[37]   Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients [J].
Niwa, T ;
Katsuzaki, T ;
Miyazaki, S ;
Miyazaki, T ;
Ishizaki, Y ;
Hayase, F ;
Tatemichi, N ;
Takei, Y .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1272-1280
[38]   Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products [J].
Ohgami, N ;
Nagai, R ;
Miyazaki, A ;
Ikemoto, M ;
Arai, H ;
Horiuchi, S ;
Nakayama, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :13348-13355
[39]   CD36, a member of the class B scavenger receptor family, as a receptor for advanced glycation end products [J].
Ohgami, N ;
Nagai, R ;
Ikemoto, M ;
Arai, H ;
Kuniyasu, A ;
Horiuchi, S ;
Nakayama, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) :3195-3202
[40]   SUPEROXIDE PRODUCTION FROM NONENZYMATICALLY GLYCATED PROTEIN [J].
SAKURAI, T ;
TSUCHIYA, S .
FEBS LETTERS, 1988, 236 (02) :406-410