Actin Filaments Regulate Exocytosis at the Hair Cell Ribbon Synapse

被引：19
作者：
Guillet, Marie
Sendin, Gaston
Bourien, Jerome
Puel, Jean-Luc
Nouvian, Regis
机构：
[1] Inst Neurosci Montpellier, INSERM, Unite Mixte Rech 1051, F-34295 Montpellier 5, France
[2] Univ Montpellier, F-34090 Montpellier, France
来源：
JOURNAL OF NEUROSCIENCE | 2016年 / 36卷 / 03期
关键词：
cochlea; membrane capacitance; patch-clamp; synaptic release; SHORT-TERM DEPRESSION; MOUSE ADRENAL SLICES; VESICLE POOL; NEUROTRANSMITTER RELEASE; TRANSMITTER RELEASE; CALCIUM-CHANNELS; AFFERENT SYNAPSE; CHROMAFFIN CELLS; RECRUITMENT; CYTOCHALASIN;
D O I：
10.1523/JNEUROSCI.3379-15.2016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exocytosis at the inner hair cell ribbon synapse is achieved through the functional coupling between calcium channels and glutamate-filled synaptic vesicles. Using membrane capacitance measurements, we investigated whether the actin network regulates the exocytosis of synaptic vesicles at the mouse auditory hair cell. Our results suggest that actin network disruption increases exocytosis and that actin filaments may spatially organize a subfraction of synaptic vesicles with respect to the calcium channels.
引用
收藏
页码：649 / 654
页数：6
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