Nucleic Acid Binding and Invitro Cytotoxicity Studies of Polymer Grafted Intercalating Copper(II) Complex

被引：2
|
作者：
Ambika, S. [1 ]
Manojkumar, Y. [1 ]
Senthilkumar, R. [2 ]
Sathiyaraj, M. [1 ]
Arunachalam, S. [1 ,3 ]
机构：
[1] Bharathidasan Univ, Sch Chem, Tiruchirappalli 620024, Tamil Nadu, India
[2] Abo Akad Univ, Dept Biosci, Cell Biol, Turku, Finland
[3] Plot 46, Tiruchirappalli 620007, Tamil Nadu, India
来源：
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2016年 / 26卷 / 03期
关键词：
Polymer anchored copper complex; Anticancer activity; DNA binding studies; DNA-BINDING; POLYMER-COPPER(II) COMPLEXES; METAL-COMPLEXES; POLYMER-COBALT(III) COMPLEXES; 1,10-PHENANTHROLINE; LIGAND; RUTHENIUM(II); BASE; PHOTOCLEAVAGE; CATALYSTS;
D O I：
10.1007/s10904-016-0356-0
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The present study on interaction of a polymer-copper(II) complex, [Cu(dpqC)(2)(BPEI)](ClO4)(2)center dot H2O (dpqC = dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro) phenazine) with CT-DNA/yeast tRNA were performed by using various spectroscopic methods. The data from these experiments suggest that the polymer-copper(II) complex binds to CT-DNA/yeast tRNA through intercalation. Furthermore, our polymer copper(II) complex showed strong binding ability with yeast tRNA than CT-DNA. It indicates that structural differences of the nucleic acids play a significant role in the binding affinity. The antiproliferative and cell death properties of this complex have been tested against MDA-MB-231 breast cancer cell line by various specific staining methods. These obtained results indicate that our complex is more cytotoxic to MDA-MB-231 breast cancer cell line.
引用
收藏
页码：579 / 588
页数：10
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