An adenosine A2A receptor gene haplotype is associated with migraine with aura

被引：32
作者：
Hohoff, C.
Marziniak, M.
Lesch, K-P
Deckert, J.
Sommer, C.
Moessner, R.
机构：
[1] Univ Munster, Dept Psychiat & Psychotherapy, D-48149 Munster, Germany
[2] Univ Wurzburg, Dept Neurol, Wurzburg, Germany
[3] Univ Saarland, Dept Neurol, D-6650 Homburg, Germany
[4] Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany
来源：
CEPHALALGIA | 2007年 / 27卷 / 02期
关键词：
adenosine A(2A) receptor; association study; haplotype; migraine with aura; polymorphisms;
D O I：
10.1111/j.1468-2982.2007.01254.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The adenosine A(2A) receptor (A2AR) facilitates effects of calcitonin gene-related peptide and vasoactive intestinal peptide, two important neuropeptides in migraine pathophysiology, and is the molecular target of caffeine, which is used in migraine treatment. We therefore determined whether A2AR gene variation might influence migraine susceptibility. Migraine patients (n = 265) with or without aura and migraine-free controls (n = 154) were assessed and genotyped for six genetic variants spanning the A2AR gene. A six-marker haplotype was more frequent in migraine patients with aura (P < 0.01) but not in patients without aura, compared with the control group. This indicates that A2AR gene variation may contribute to the pathogenesis of migraine with aura.
引用
收藏
页码：177 / 181
页数：5
相关论文
共 19 条
  • [1] Association between A2a receptor gene polymorphisms and caffeine-induced anxiety
    Alsene, K
    Deckert, J
    Sand, P
    de Wit, H
    [J]. NEUROPSYCHOPHARMACOLOGY, 2003, 28 (09) : 1694 - 1702
  • [2] Haploview: analysis and visualization of LD and haplotype maps
    Barrett, JC
    Fry, B
    Maller, J
    Daly, MJ
    [J]. BIOINFORMATICS, 2005, 21 (02) : 263 - 265
  • [3] Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease
    Deckert, J
    Nothen, MM
    Franke, P
    Delmo, C
    Fritze, J
    Knapp, M
    Maier, W
    Beckmann, H
    Propping, P
    [J]. MOLECULAR PSYCHIATRY, 1998, 3 (01) : 81 - 85
  • [4] The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study
    Diener, HC
    Pfaffenrath, V
    Pageler, L
    Peil, H
    Aicher, B
    [J]. CEPHALALGIA, 2005, 25 (10) : 776 - 787
  • [5] Update on the genetics of migraine
    Estevez, M
    Gardner, KL
    [J]. HUMAN GENETICS, 2004, 114 (03) : 225 - 235
  • [6] Another migraine gene
    Goadsby, PJ
    Kullmann, DM
    [J]. LANCET, 2005, 366 (9483) : 345 - 346
  • [7] Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission
    Goadsby, PJ
    Hoskin, KL
    Storer, RJ
    Edvinsson, L
    Connor, HE
    [J]. BRAIN, 2002, 125 : 1392 - 1401
  • [8] Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder
    Hamilton, SP
    Slager, SL
    de Leon, AB
    Heiman, GA
    Klein, DF
    Hodge, SE
    Weissman, MM
    Fyer, AJ
    Knowles, JA
    [J]. NEUROPSYCHOPHARMACOLOGY, 2004, 29 (03) : 558 - 565
  • [9] Kern Ralph Z., 2005, Headache, V45, P251, DOI 10.1111/j.1526-4610.2005.05053_4.x
  • [10] PATHOPHYSIOLOGY OF THE MIGRAINE AURA - THE SPREADING DEPRESSION THEORY
    LAURITZEN, M
    [J]. BRAIN, 1994, 117 : 199 - 210
12