Detection of Novel Sequences Related to African Swine Fever Virus in Human Serum and Sewage

被引：38

作者：

Loh, Joy ^{[1
,2
]}

Zhao, Guoyan ^{[1
,2
]}

Presti, Rachel M. ^{[3
]}

Holtz, Lori R. ^{[4
]}

Finkbeiner, Stacy R. ^{[1
,2
]}

Droit, Lindsay ^{[1
,2
]}

Villasana, Zoilmar ^{[1
,2
]}

Todd, Collin ^{[1
,2
]}

Pipas, James M. ^{[5
]}

Calgua, Byron ^{[6
]}

Girones, Rosina ^{[6
]}

Wang, David ^{[1
,2
]}

Virgin, Herbert W. ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Dept Mol Microbiol, Sch Med, St Louis, MO 63110 USA

[3] Washington Univ, Dept Med, Sch Med, St Louis, MO 63110 USA

[4] Washington Univ, Dept Pediat, Sch Med, St Louis, MO 63110 USA

[5] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

[6] Univ Barcelona, Fac Biol, Dept Microbiol, Barcelona, Spain

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 24期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE-SEQUENCE; GENE; PROTEINS; HOMOLOGY; ORIGIN; IDENTIFICATION; EPIDEMIOLOGY; EVOLUTION; MIMIVIRUS; ENCODES;

D O I：

10.1128/JVI.00638-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

引用

页码：13019 / 13025

页数：7

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