Auditory Stimulation Modulates Resting-State Functional Connectivity in Unresponsive Wakefulness Syndrome Patients

被引：10

作者：

Boltzmann, Melanie ^{[1
]}

Schmidt, Simone B. ^{[1
]}

Gutenbrunner, Christoph ^{[2
]}

Krauss, Joachim K. ^{[3
]}

Stangel, Martin ^{[4
]}

Hoeglinger, Gunter U. ^{[4
]}

Wallesch, Claus-W. ^{[5
]}

Muente, Thomas F. ^{[6
]}

Rollnik, Jens D. ^{[1
]}

机构：

[1] BDH Klin Hessisch Oldendorf, Hessisch Oldendorf, Germany

[2] Hannover Med Sch, Clin Rehabil Med, Hannover, Germany

[3] Hannover Med Sch, Dept Neurosurg, Hannover, Germany

[4] Hannover Med Sch, Dept Neurol, Hannover, Germany

[5] BDH Klin Elzach, Elzach, Germany

[6] Univ Lubeck, Dept Neurol, Lubeck, Germany

来源：

FRONTIERS IN NEUROSCIENCE | 2021年 / 15卷

关键词：

neurological early rehabilitation; disorders of consciousness; unresponsive wakefulness syndrome; auditory stimulation; resting-state fMRI; MINIMALLY CONSCIOUS STATE; DEFAULT MODE NETWORK; OWN NAME; CEREBRAL RESPONSE; VEGETATIVE STATE; MUSIC-THERAPY; DISORDERS; RECOVERY; LEVEL; AWARENESS;

D O I：

10.3389/fnins.2021.554194

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Passive listening to music is associated with several psychological and physical benefits in both, healthy and diseased populations. In this fMRI study, we examined whether preferred music has effects on the functional connectivity within resting-state networks related to consciousness. Thirteen patients in unresponsive wakefulness syndrome (UWS) and 18 healthy controls (HC) were enrolled. Both groups were exposed to different auditory stimulation (scanner noise, preferred music, and aversive auditory stimulation). Functional connectivity was analyzed using a seed-based approach. In HC, no differences were found between the three conditions, indicating that their networks are already working at high level. UWS patients showed impaired functional connectivity within all resting-state networks. In addition, functional connectivity of the auditory network was modulated by preferred music and aversive auditory stimulation. Hence, both conditions have the potential to modulate brain activity of UWS patients.

引用

页数：11

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