The Association of Specific Constituents of the Fecal Microbiota with Immune-Mediated Brain Disease in Dogs

被引:27
作者
Jeffery, Nick D. [1 ,2 ]
Barker, Andrew K. [1 ,3 ]
Alcott, Cody J. [1 ,4 ]
Levine, Jon M. [2 ]
Meren, Ilyssa [1 ]
Wengert, Jane [1 ]
Jergens, Albert E. [1 ]
Suchodolski, Jan S. [2 ]
机构
[1] Iowa State Univ, Coll Vet Med, Dept Vet Clin Studies, Ames, IA 50011 USA
[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX 77843 USA
[3] Toronto Vet Emergency Hosp, Scarborough, ON, Canada
[4] Vet Specialty Ctr Tucson, Tucson, AZ USA
关键词
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GUT MICROBIOTA; NECROTIZING MENINGOENCEPHALITIS; MULTIPLE-SCLEROSIS; GRANULOMATOUS MENINGOENCEPHALOMYELITIS; VITAMIN-D; RISK; OPPORTUNITY; POPULATION; INDUCTION;
D O I
10.1371/journal.pone.0170589
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Meningoencephalomyelitis of unknown origin (MUO) is a common, naturally-occurring, clinical disease of pet dogs. It is an immune-mediated condition that has many similarities with experimental autoimmune encephalitis (EAE) in rodents and so investigation of its pathogenesis may aid in understanding factors that contribute to development of multiple sclerosis in people. Gut microbiota are known to modulate immune responses that influence susceptibility to immune-mediated brain disease. In this study we aimed to compare abundance of specific constituents of the fecal microbiota, namely Faecalibacterium prausnitzii and Prevotellaceae, between dogs diagnosed with MUO and matched controls. Fecal samples were obtained from 20 dogs diagnosed with MUO and 20 control dogs matched for breed, age and gender. Bacterial abundance was measured using qPCR and 16S rRNA sequencing. We found that Prevotellaceae were significantly less abundant in cases compared with controls (p = 0.003) but there was no difference in abundance of F. prausnitzii. There was no evidence of other differences in gut microbiota between groups. These data, derived from this naturally-occurring canine clinical model, provide strong corroborative evidence that high abundance of Prevotellaceae in the gut is associated with reduced risk for developing immune-mediated brain disease.
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页数:14
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