Minor ABO-Mismatches are Risk Factors for Acute Graft-versus-Host Disease in Hematopoietic Stem Cell Transplant Patients

被引：26

作者：

Ludajic, Katarina ^{[1
]}

Balavarca, Yesilda ^{[2
]}

Bickeboeller, Heike ^{[2
]}

Rosenmayr, Agathe ^{[1
]}

Fischer, Gottfried F. ^{[1
]}

Fae, Ingrid ^{[1
]}

Kalhs, Peter ^{[3
]}

Pohlreich, David ^{[3
]}

Kouba, Michal ^{[3
]}

Dobrovolna, Marie ^{[4
]}

Greinix, Hildegard T. ^{[3
]}

机构：

[1] Med Univ Wien, Klin Abt Blutgrp Serol, Div Blood Grp Serol, A-1090 Vienna, Austria

[2] Univ Gottingen, Univ Med Ctr, Dept Genet Epidemiol, D-3400 Gottingen, Germany

[3] Med Univ Wien, Dept Internal Med 1, A-1090 Vienna, Austria

[4] Inst Hematol & Blood Transfus, Natl Reference Lab DNA Diagnost, CR-12820 Prague, Czech Republic

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2009年 / 15卷 / 11期

关键词：

Minor ABO-mismatch; Rh antigen; aGVHD; unrelated HSCT; BONE-MARROW-TRANSPLANTATION; MATCHED UNRELATED DONORS; HISTOCOMPATIBILITY ANTIGENS; IDENTICAL SIBLINGS; INCOMPATIBILITY; RECIPIENT; SURVIVAL; OUTCOMES; THERAPY; ALLELES;

D O I：

10.1016/j.bbmt.2009.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the impact of ABO and Rhesus (Rh) blood group matching on the outcome of hematopoietic stem cell transplantation (HSCT) of 154 patients matched at 10/10 HLA loci with unrelated donors. ABO and Rh, as potential risk factors, were modeled with the clinical outcome-acute and chronic graft-versus-host disease (aGVHD, cGVHD), relapse, treatment-related mortality (TRM), and overall survival (OS)-by simple, multiple, and competing risk analyses. We found that minor ABO-mismatches represent a significant risk factor for aGVHD (II-IV) with an estimated risk increase of almost 3-fold (hazard ratio [HR] = 2.92,95% confidence interval [CI]: 1.43-5.95, P = .003), and even 4-fold for aGVHD (III-IV) (HR = 4.24,95% CI: 1.70-10.56, P = .002), but not for other transplant endpoints. No significant association of the Rh matching status with any of the HSCT endpoints was seen. These results suggest that ABO minor mismatches may play a role in aGvHD pathophysiology, possibly by providing the setting for T cell activation and antibody mediated damage. To decrease the risk of aGVHD, ABO matching should be considered in HSCT Biol Blood Marrow Transplant 15: 1400-1406 (2009) (C) 2009 American Society for Blood and Marrow Transplantation

引用

页码：1400 / 1406

页数：7

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