Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis

被引：27
作者：
Alvarenga, Marcos Papais [1 ,2 ,3 ]
do Carmo, Luciana Ferreira [1 ]
Ferreira Vasconcelos, Claudia Cristina [1 ]
Alvarenga, Marina Papais [1 ]
Alvarenga-Filho, Helcio [1 ,3 ]
de Melo Bento, Cleonice Alves [1 ]
Antao Paiva, Carmen Lucia [1 ]
Leyva-Fernandez, Laura [4 ,5 ]
Fernandez, Oscar [6 ]
Papais-Alvarenga, Regina Maria [1 ,2 ]
机构：
[1] Univ Fed Estado Rio de Janeiro UNIRIO, Programa Posgrad Neurol, Rua Mariz & Barros 775, BR-20270004 Rio De Janeiro, RJ, Brazil
[2] Hosp Fed Lagoa, Dept Neurol, Rua Jardim Bot 501, BR-22470050 Rio De Janeiro, RJ, Brazil
[3] Univ Estacio Sa UNESA, Ave Ayrton Senna 2800, BR-22775003 Rio De Janeiro, RJ, Brazil
[4] Hosp Reg Univ Malaga, UGCNeurociencias, Inst Invest Biomed Malaga IBIMA, Ave Carlos Haya Sn, Malaga 29010, Spain
[5] Red Temat Invest Cooperat Red Espanola Esclerosis, Barcelona, Spain
[6] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Ave Carlos Haya Sn, Malaga 29010, Spain
来源：
SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期
关键词：
CLASS-II; DIAGNOSTIC-CRITERIA; SUSCEPTIBILITY; SPECTRUM; ALLELES; RISK; PATHOGENESIS; HAPLOTYPES; ANTIBODY; MARKER;
D O I：
10.1038/s41598-020-80535-3
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB1*03 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB1*03:01 allele in Western populations and with the DPB1*05:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.
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页数：14
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