Effects of Anti-dementia Drugs on Morphine-Induced Somnolence

被引：3

作者：

Ishida, Takayuki ^{[1
]}

Suga, Asami ^{[1
]}

Akagi, Masaaki ^{[2
]}

Kamei, Chiaki ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med Pharmacol, Kita Ku, Okayama 7008530, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Dept Pharmacol, Yamashiro, Tokushima 7708514, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2009年 / 32卷 / 11期

关键词：

morphine; opioid; anti-dementia drug; methylphenidate; somnolence; VENTRAL TEGMENTAL AREA; SLEEP-DISTURBED RATS; RECEPTORS; STATE; BEHAVIOR; NEURONS; ACID; PAIN; MICE;

D O I：

10.1248/bpb.32.1862

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to investigate the characteristics of morphine in rat sleep patterns and also the effects of donepezil and memantine on somnolence caused by morphine. Electrodes were chronically implanted into the cortex and dorsal neck muscle of rats for electroencephalogram (EEG) and electromyogram (EMG) recordings, respectively. EEG and EMG were recorded with an electroencephalograph. SleepSigh ver.2.0, was used to analyse the sleep-wake state. Total times of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep were measured from 10:00 to 16:00. Morphine at a high dose caused a significant decrease in sleep latency and total REM sleep time, although the drug at low doses caused significant increases in sleep latency and total awake time, and a significant decrease in NREM sleep time. Donepezil, memantine and methylphenidate antagonized the decrease in sleep latency caused by morphine. From these findings, it can be concluded that morphine caused somnolence, and donepezil and memantine are useful for somnolence caused by morphine, similar to methylphenidate.

引用

页码：1862 / 1865

页数：4

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