Protein uptake into individual hydrogel microspheres visualized by high-speed atomic force microscopy

被引：16

作者：

Matsui, Shusuke ^{[1
]}

Hosho, Kensuke ^{[1
]}

Minato, Haruka ^{[1
]}

Uchihashi, Takayuki ^{[2
,3
,4
]}

Suzuki, Daisuke ^{[1
,5
]}

机构：

[1] Shinshu Univ, Grad Sch Text Sci & Technol, 3-15-1 Tokida, Ueda, Nagano 3868567, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Phys, Nagoya, Aichi 4648602, Japan

[3] Nagoya Univ, Grad Sch Sci, Struct Biol Res Ctr, Nagoya, Aichi 4648602, Japan

[4] Natl Inst Nat Sci, Exploratory Res Ctr Life & Living Syst, 5-1 Higashiyama, Okazaki, Aichi 4448787, Japan

[5] Shinshu Univ, Interdisciplinary Cluster Cutting Edge Res, Res Initiat Supra Mat, 3-15-1 Tokida, Ueda, Nagano 3868567, Japan

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 68期

基金：

日本学术振兴会;

关键词：

SYNTHETIC-POLYMER NANOPARTICLES; MICROGELS; ADSORPTION; LYSOZYME; PEPTIDE; DESIGN; CORONA;

D O I：

10.1039/c9cc05116c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Themoment of protein uptake into hydrogel microspheres (microgels) was directly monitored at the nanoscale by high-speed atomic force microscopy. The dynamic morphological changes in the microgels during protein uptake are largely different depending on the type of protein, and the properties and structure of the microgels, which would affect the colloidal stability of protein-microgel hybrids both in vitro and in vivo.

引用

页码：10064 / 10067

页数：4

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