Somatostatin, Alzheimer's disease and cognition: An old story coming of age?

被引：72
作者：
Epelbaum, Jacques [1 ]
Guillou, Jean-Louis [2 ]
Gastambide, Francois [2 ]
Hoyer, Daniel [3 ]
Duron, Emmanuelle [1 ]
Viollet, Cecile [1 ]
机构：
[1] Univ Paris 05, Ctr Psychiat & Neurosci, UMR 894, INSERM,Fac Med, F-75014 Paris, France
[2] Univ Bordeaux 1, Ctr Neurosci Integrat & Cognit, UMR 5228, CNRS, F-33405 Talence, France
[3] Novartis Inst BioMed Res Basel, CH-4002 Basel, Switzerland
来源：
PROGRESS IN NEUROBIOLOGY | 2009年 / 89卷 / 02期
关键词：
Somatostatin; Cortistatin; beta amyloid; Tau; Cysteamine; sst(2); sst(4); Hippocampus; Striatum; LONG-TERM POTENTIATION; FK960 N-(4-ACETYL-1-PIPERAZINYL)-P-FLUOROBENZAMIDE MONOHYDRATE; INTRACEREBROVENTRICULARLY ADMINISTERED SOMATOSTATIN; DORSOLATERAL PREFRONTAL CORTEX; RESPONSE LEARNING-STRATEGIES; CYSTEAMINE-INDUCED DEPLETION; DIFFERENT BEHAVIORAL-TESTS; MOSSY FIBER-CA3 SYSTEM; SHOCK-INDUCED AMNESIA; AMYLOID-BETA PEPTIDE;
D O I：
10.1016/j.pneurobio.2009.07.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In mammalian brain, the somatostatin (SRIF: somatotropin release-inhibiting factor) family is composed of two peptides: SRIF and cortistatin (CST), which interact with five different receptor subtypes, sst(1-5). This review summarizes the properties of these receptors, the involvement of somatostatinergic systems in Alzheimer's disease (SRIF/acetylcholine (Ach), SRIF/amyloid beta peptides, and SRIF/tau interactions) and their role in cognition from early studies using cysteamine as an SRIF depleting substance to the use of subtype selective analogues and knockout mice, and modulation of synaptic plasticity. The current SRIF story illustrates how cognition and emotion are intimately integrated in brain function. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：153 / 161
页数：9
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