Halorosellins A and B, unique isocoumarin glucosides from the marine fungus Halorosellinia oceanica

被引：82

作者：

Chinworrungsee, M

Kittakoop, P ^{[1
]}

Isaka, M

Chanphen, R

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[2] VSTDA, Natl Ctr Genet Engn & Biotechnol, Pathum Thani 12120, Thailand

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2002年 / 22期

关键词：

D O I：

10.1039/b207887m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structurally unique isocoumarin glucosides, named halorosellins A ( 1) and B ( 2), were isolated from the EtOAc extract of a broth of the marine fungus Halorosellinia oceanica. Other new minor metabolites including 4,8-dihydroxy-6-methoxy-4,5-dimethyl- 3-methyleneisochroman-1-one (3), 3-acetyl-7-hydroxy-5-methoxy-3,4-dimethyl-3-H-isobenzofuran-1-one ( 4) and an ophiobolane sesterterpene, 17-dehydroxyhalorosellinic acid ( 5), were also isolated. Structures of these compounds were elucidated by analyses of spectroscopic data. Compound 4 exhibited mild antimycobacterial activity (MIC value of 200 mug mL(-1)).

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页码：2473 / 2476

页数：4

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