The role of the clinical biochemist in detection of zinc-induced copper deficiency

被引：7
作者：
Duncan, A. [1 ]
Gallacher, G. [2 ]
Willox, L. [1 ]
机构：
[1] Glasgow Royal Infirm, Scottish Trace Element & Micronutrient Reference, Glasgow G4 0SF, Lanark, Scotland
[2] Hairmyres Hosp, Dept Biochem, E Kilbride, Lanark, Scotland
来源：
ANNALS OF CLINICAL BIOCHEMISTRY | 2016年 / 53卷 / 02期
关键词：
Neurological disorders; clinical studies; toxicology; DISEASE; HYPOCUPREMIA; MYELOPATHY;
D O I：
10.1177/0004563215595429
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
A middle-aged woman with neutropenia and ataxia was found to have raised plasma zinc and profoundly low plasma copper concentrations. When found that she had been prescribed 135mg zinc/day for seven years, a diagnosis of zinc-induced copper deficiency was made. After the zinc prescription was stopped, her copper and zinc concentrations and neutropenia normalized but she only had partial improvement in neurological status. The diagnosis of zinc-induced copper deficiency can be facilitated by the laboratory through measurement of plasma zinc concentration in patients with a low plasma copper concentration.
引用
收藏
页码：298 / 301
页数：4
相关论文
共 23 条
[1]  
[Anonymous], 2006, GUIDELINES FOOD FORT
[2]   TREATMENT OF WILSONS-DISEASE WITH ZINC-XII - DOSE REGIMEN REQUIREMENTS [J].
BREWER, GJ ;
YUZBASIYANGURKAN, V ;
JOHNSON, V ;
DICK, RD ;
WANG, YX .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1993, 305 (04) :199-202
[3]  
Duncan A, J CLIN PATHOL, DOI [10.1136/jclin-path-2014-202837, DOI 10.1136/JCLIN-PATH-2014-202837]
[4]   Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements [J].
Duncan, Andrew ;
Talwar, Dinesh ;
McMillan, Donald C. ;
Stefanowicz, Fiona ;
O'Reilly, Denis St J. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 95 (01) :64-71
[5]  
Festa DM., 1985, AM J CLIN NUTR, V41, P285
[6]  
Food Standards Agency, 2010, EAT WELL BE WELL
[7]   Hypocupremia associated cytopenia and myelopathy: a national retrospective review [J].
Gabreyes, Alemayehu A. ;
Abbasi, Hina Naz ;
Forbes, Kirsten P. ;
McQuaker, Grant ;
Duncan, Andrew ;
Morrison, Ian .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2013, 90 (01) :1-9
[8]   Hematological manifestations of copper deficiency: a retrospective review [J].
Halfdanarson, Thorvardur R. ;
Kumar, Neeraj ;
Li, Chin-Yang ;
Phyliky, Robert L. ;
Hogan, William J. .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2008, 80 (06) :523-531
[9]   COPPER-THIONEIN FROM FETAL BOVINE LIVER [J].
HARTMANN, HJ ;
WESER, U .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 491 (01) :211-222
[10]   Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin - Further support for existence of a new zinc overload syndrome [J].
Hedera, P ;
Fink, JK ;
Bockenstedt, PL ;
Brewer, GJ .
ARCHIVES OF NEUROLOGY, 2003, 60 (09) :1303-1306
123