Fertility, Pregnancy, and Lactation in Rheumatoid Arthritis

被引：37

作者：

de Jong, Pascal H. P. ^{[1
]}

Dolhain, Radboud J. E. M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Rheumatol, Postbus 2040, NL-3000 CA Rotterdam, Netherlands

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 02期

关键词：

Rheumatoid arthritis; Pregnancy; Fertility; Disease activity; Lactation; ANTI-MULLERIAN HORMONE; DISEASE-ACTIVITY; ALPHA INHIBITORS; OVARIAN RESERVE; INCREASED RISK; WOMEN; OUTCOMES; INFERTILITY; NATIONWIDE; GLUCOCORTICOIDS;

D O I：

10.1016/j.rdc.2016.12.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fertility is impaired in women with rheumatoid arthritis (RA), whereas less is known about male fertility problems. Pregnancy outcome in patients with RA is slightly less favorable compared with the general population, especially in patients with active disease. Disease activity usually improves during pregnancy, but less than previously thought. Although several anti rheumatic drugs are contraindicated in pregnancy, more treatment options are available. There is evidence on the safety of TNF inhibitors in pregnancy. Given the impact of active disease on fertility and pregnancy outcome, a treat-to-target strategy is recommended for patients who are pregnant or have a wish to conceive.

引用

页码：227 / +

页数：12

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