Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

被引:193
作者
Cavalli, Andrea [1 ,2 ]
Bolognesi, Maria Laura [1 ]
机构
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy
关键词
HUMAN AFRICAN TRYPANOSOMIASIS; REDUCTASE-THYMIDYLATE SYNTHASE; FATTY-ACID SYNTHESIS; CHAGAS-DISEASE; DRUG DISCOVERY; VISCERAL LEISHMANIASIS; BRUCEI-RHODESIENSE; SLEEPING SICKNESS; NATURAL-PRODUCTS; METAL-COMPLEXES;
D O I
10.1021/jm9004835
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:7339 / 7359
页数:21
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共 180 条
[71]   Current concepts - Control of neglected tropical diseases [J].
Hotez, Peter J. ;
Molyneux, David H. ;
Fenwick, Alan ;
Kumaresan, Jacob ;
Sachs, Sonia Ehrlich ;
Sachs, Jeffrey D. ;
Savioli, Lorenzo .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (10) :1018-1027
[72]   Histone deacetylases in Trypanosoma brucei:: two are essential and another is required for normal cell cycle progression [J].
Ingram, AK ;
Horn, D .
MOLECULAR MICROBIOLOGY, 2002, 45 (01) :89-97
[73]   The genome of the kinetoplastid parasite, Leishmania major [J].
Ivens, AC ;
Peacock, CS ;
Worthey, EA ;
Murphy, L ;
Aggarwal, G ;
Berriman, M ;
Sisk, E ;
Rajandream, MA ;
Adlem, E ;
Aert, R ;
Anupama, A ;
Apostolou, Z ;
Attipoe, P ;
Bason, N ;
Bauser, C ;
Beck, A ;
Beverley, SM ;
Bianchettin, G ;
Borzym, K ;
Bothe, G ;
Bruschi, CV ;
Collins, M ;
Cadag, E ;
Ciarloni, L ;
Clayton, C ;
Coulson, RMR ;
Cronin, A ;
Cruz, AK ;
Davies, RM ;
De Gaudenzi, J ;
Dobson, DE ;
Duesterhoeft, A ;
Fazelina, G ;
Fosker, N ;
Frasch, AC ;
Fraser, A ;
Fuchs, M ;
Gabel, C ;
Goble, A ;
Goffeau, A ;
Harris, D ;
Hertz-Fowler, C ;
Hilbert, H ;
Horn, D ;
Huang, YT ;
Klages, S ;
Knights, A ;
Kube, M ;
Larke, N ;
Litvin, L .
SCIENCE, 2005, 309 (5733) :436-442
[74]   An overview of Chagas disease treatment [J].
Jannin, Jean ;
Villa, Luis .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2007, 102 :95-97
[75]   Identification of potential multitarget antimalarial drugs [J].
Jenwitheesuk, E ;
Samudrala, R .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (12) :1490-1491
[76]   Novel paradigms for drug discovery: computational multitarget screening [J].
Jenwitheesuk, Ekachai ;
Horst, Jeremy A. ;
Rivas, Kasey L. ;
Van Voorhis, Wesley C. ;
Samudrala, Ram .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2008, 29 (02) :62-71
[77]   A phase II dose-ranging study of sitamaquine for the treatment of visceral leishmaniasis in India [J].
Jha, Tara K. ;
Sundar, Shyam ;
Thakur, Chandreshwar P. ;
Sabin, Antony J. ;
Horton, John ;
Felton, J. Mark .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 73 (06) :78-78
[78]   Treatment of leishmaniasis with miltefosine: 2008 status [J].
Berman, Jonathan .
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2008, 4 (09) :1209-1216
[79]   Natural products as antiparasitic drugs [J].
Kayser, O ;
Kiderlen, AF ;
Croft, SL .
PARASITOLOGY RESEARCH, 2003, 90 (Suppl 2) :S55-S62
[80]   Designing Sleeping Sickness Control [J].
Kinoshita, Taroh .
ACS CHEMICAL BIOLOGY, 2008, 3 (10) :601-603