Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

被引：193
作者：
Cavalli, Andrea [1 ,2 ]
Bolognesi, Maria Laura [1 ]
机构：
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 23期
关键词：
HUMAN AFRICAN TRYPANOSOMIASIS; REDUCTASE-THYMIDYLATE SYNTHASE; FATTY-ACID SYNTHESIS; CHAGAS-DISEASE; DRUG DISCOVERY; VISCERAL LEISHMANIASIS; BRUCEI-RHODESIENSE; SLEEPING SICKNESS; NATURAL-PRODUCTS; METAL-COMPLEXES;
D O I：
10.1021/jm9004835
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：7339 / 7359
页数：21
相关论文
共 180 条
[31]   The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure [J].
Cavalcanti, DP ;
Fragoso, SP ;
Goldenberg, S ;
de Souza, W ;
Motta, MCM .
PARASITOLOGY RESEARCH, 2004, 94 (06) :439-448
[32]   Multi-target-directed ligands to combat neurodegenerative diseases [J].
Cavalli, Andrea ;
Bolognesi, Maria Laura ;
Minarini, Anna ;
Rosini, Michela ;
Tumiatti, Vincenzo ;
Recanatini, Maurizio ;
Melchiorre, Carlo .
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (03) :347-372
[33]   Pharmacological properties of furoxans and benzofuroxans: Recent developments [J].
Cerecetto, H ;
Porcal, W .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (01) :57-71
[34]   Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? [J].
Chappuis, Francois ;
Sundar, Shyam ;
Hailu, Asrat ;
Ghalib, Hashim ;
Rijal, Suman ;
Peeling, Rosanna W. ;
Alvar, Jorge ;
Boelaert, Marleen .
NATURE REVIEWS MICROBIOLOGY, 2007, 5 (11) :873-882
[35]   Trypanosome alternative oxidase: from molecule to function [J].
Chaudhuri, Minu ;
Ott, Robert Daniel ;
Hill, George C. .
TRENDS IN PARASITOLOGY, 2006, 22 (10) :484-491
[36]   Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals [J].
Chen, Donald ;
Marsh, Rebecca ;
Aberg, Judith A. .
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2007, 5 (06) :921-928
[37]   Towards broadspectrum antiprotozoal agents [J].
Chibale, K .
ARKIVOC, 2002, :93-98
[38]   Selection of a trioxaquine as an antimalarial drug candidate [J].
Cosledan, Frederic ;
Fraisse, Laurent ;
Pellet, Alain ;
Guillou, Francois ;
Mordmueller, Benjamin ;
Kremsner, Peter G. ;
Moreno, Alicia ;
Mazier, Dominique ;
Maffrand, Jean-Pierre ;
Meunier, Bernard .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17579-17584
[39]   Kinetoplastida: New therapeutic strategies [J].
Croft, S. L. .
PARASITE, 2008, 15 (03) :522-527
[40]   Drug resistance in leishmaniasis [J].
Croft, SL ;
Sundar, S ;
Fairlamb, AH .
CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (01) :111-+
12345678910