Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

被引:193
作者
Cavalli, Andrea [1 ,2 ]
Bolognesi, Maria Laura [1 ]
机构
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy
关键词
HUMAN AFRICAN TRYPANOSOMIASIS; REDUCTASE-THYMIDYLATE SYNTHASE; FATTY-ACID SYNTHESIS; CHAGAS-DISEASE; DRUG DISCOVERY; VISCERAL LEISHMANIASIS; BRUCEI-RHODESIENSE; SLEEPING SICKNESS; NATURAL-PRODUCTS; METAL-COMPLEXES;
D O I
10.1021/jm9004835
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:7339 / 7359
页数:21
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共 180 条
[111]   Current developments in the synthesis and biological activity of HIV-1 double-drug inhibitors [J].
Muhanji, Clare I. ;
Hunter, Roger .
CURRENT MEDICINAL CHEMISTRY, 2007, 14 (11) :1207-1220
[112]   Thiol-based redox metabolism of protozoan parasites [J].
Müller, S ;
Liebau, E ;
Walter, RD ;
Krauth-Siegel, RL .
TRENDS IN PARASITOLOGY, 2003, 19 (07) :320-328
[113]   Advances in leishmaniasis [J].
Murray, HW ;
Berman, JD ;
Davies, CR ;
Saravia, NG .
LANCET, 2005, 366 (9496) :1561-1577
[114]   Chemogenomics and parasitology: Small molecules and cell-based assays to study infectious processes [J].
Muskavitch, Marc A. T. ;
Barteneva, Natasha ;
Gubbels, Marc-Jan .
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2008, 11 (08) :624-646
[115]   Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity [J].
Musonda, Chitalu C. ;
Whitlock, Gavin A. ;
Witty, Michael J. ;
Brun, Reto ;
Kaiser, Marcel .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (02) :481-484
[116]   Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes [J].
Mutomba, MC ;
To, WY ;
Hyun, WC ;
Wang, CC .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 90 (02) :491-504
[117]   The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major [J].
Nare, B ;
Hardy, LW ;
Beverley, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (21) :13883-13891
[118]   Trypanosome alternative oxidase as a target of chemotherapy [J].
Nihei, C ;
Fukai, Y ;
Kita, K .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3) :234-239
[119]   Antitrypanosomal activities of proteasome inhibitors [J].
Nkemgu-Njinkeng, J ;
Rosenkranz, V ;
Wink, M ;
Steverding, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :2038-2040
[120]   Effective measures for controlling trypanosomiasis [J].
Nok, AJ .
EXPERT OPINION ON PHARMACOTHERAPY, 2005, 6 (15) :2645-2653