Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

被引：193
作者：
Cavalli, Andrea [1 ,2 ]
Bolognesi, Maria Laura [1 ]
机构：
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 23期
关键词：
HUMAN AFRICAN TRYPANOSOMIASIS; REDUCTASE-THYMIDYLATE SYNTHASE; FATTY-ACID SYNTHESIS; CHAGAS-DISEASE; DRUG DISCOVERY; VISCERAL LEISHMANIASIS; BRUCEI-RHODESIENSE; SLEEPING SICKNESS; NATURAL-PRODUCTS; METAL-COMPLEXES;
D O I：
10.1021/jm9004835
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：7339 / 7359
页数：21
相关论文
共 180 条
[1]   Genomic-scale prioritization of drug targets: the TDR Targets database [J].
Agueero, Fernan ;
Al-Lazikani, Bissan ;
Aslett, Martin ;
Berriman, Matthew ;
Buckner, Frederick S. ;
Campbell, Robert K. ;
Carmona, Santiago ;
Carruthers, Ian M. ;
Chan, A. W. Edith ;
Chen, Feng ;
Crowther, Gregory J. ;
Doyle, Maria A. ;
Hertz-Fowler, Christiane ;
Hopkins, Andrew L. ;
McAllister, Gregg ;
Nwaka, Solomon ;
Overington, John P. ;
Pain, Arnab ;
Paolini, Gala V. ;
Pieper, Ursula ;
Ralph, Stuart A. ;
Riechers, Aaron ;
Roos, David S. ;
Sali, Andrej ;
Shanmugam, Dhanasekaran ;
Suzuki, Takashi ;
Van Voorhis, Wesley C. ;
Verlinde, Christophe L. M. J. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (11) :900-907
[2]   On the origin, evolution, and nature of programmed cell death: a timeline of four billion years [J].
Ameisen, JC .
CELL DEATH AND DIFFERENTIATION, 2002, 9 (04) :367-393
[3]   O-alkoxyamidine prodrugs of furamidine:: In vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection [J].
Ansede, JH ;
Anbazhagan, M ;
Brun, R ;
Easterbrook, JD ;
Hall, JE ;
Boykin, DW .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (17) :4335-4338
[4]   Newer triazole antifungal agents: pharmacology, spectrum, clinical efficacy and limitations [J].
Aperis, George ;
Mylonakis, Eleftherios .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2006, 15 (06) :579-602
[5]   Drug hybrids enter the fray [J].
Arnaud, Celia Henry .
CHEMICAL & ENGINEERING NEWS, 2007, 85 (46) :46-+
[6]   Inactivation of parasite cysteine proteinases by the NO-donor 4-(phenylsulfonyl)-3-((2-(dimethylamino)ethyl)thio)-furoxan oxalate [J].
Ascenzi, P ;
Bocedi, A ;
Gentile, M ;
Visca, P ;
Gradoni, L .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2004, 1703 (01) :69-77
[7]   Molecular Basis of Antimony Treatment in Leishmaniasis [J].
Baiocco, Paola ;
Colotti, Gianni ;
Franceschini, Stefano ;
Ilari, Andrea .
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (08) :2603-2612
[8]   Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo [J].
Balasegaram, Manica ;
Harris, Steve ;
Checchi, Francesco ;
Hamel, Catherine ;
Karunakara, Unni .
BULLETIN OF THE WORLD HEALTH ORGANIZATION, 2006, 84 (10) :777-782
[9]   Network biology:: Understanding the cell's functional organization [J].
Barabási, AL ;
Oltvai, ZN .
NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15
[10]   Antimalarial dosing regimens and drug resistance [J].
Barnes, Karen I. ;
Watkins, William M. ;
White, Nicholas J. .
TRENDS IN PARASITOLOGY, 2008, 24 (03) :127-134
12345678910