Treatment-resistant bipolar depression: towards a new definition

被引：51

作者：

Pacchiarotti, I. ^{[1
,2
]}

Mazzarini, L. ^{[1
,2
]}

Colom, F. ^{[1
]}

Sanchez-Moreno, J. ^{[1
]}

Girardi, P. ^{[2
]}

Kotzalidis, G. D. ^{[2
]}

Vieta, E. ^{[1
]}

机构：

[1] Univ Barcelona, Bipolar Disorders Programme, Inst Clin Neurosci, Hosp Clin,CIBERSAM, Barcelona, Spain

[2] Univ Roma La Sapienza, Sch Med 2, Dept Neurosci, Unit Psychiat,St Andrea Hosp, Rome, Italy

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2009年 / 120卷 / 06期

关键词：

bipolar disorder; treatment-resistant; bipolar depression; evidence-based guidelines; PLACEBO-CONTROLLED TRIAL; ANXIETY TREATMENTS CANMAT; DOUBLE-BLIND; I DISORDER; MOOD STABILIZERS; ANTIDEPRESSANT TREATMENT; UNIPOLAR DEPRESSION; CANADIAN NETWORK; CLINICAL-TRIALS; SINGLE-BLIND;

D O I：

10.1111/j.1600-0447.2009.01471.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To summarize the conceptual and operational definitions of treatment-resistant bipolar depression and to review the evidence-based therapeutic options. Method: Structured searches of PubMed, Index Medicus, Excerpta Medica and Psyclit conducted in December 2008. Results: Criteria for treatment resistance in bipolar depression are commonly based on concepts stemming from treatment resistance as defined for unipolar depression, an approach that proved to be inadequate. In fact, the addition of an ad hoc criterion based on lithium and other mood stabilizer unresponsiveness after reaching adequate plasma levels appears to be a patch that attempts to take into account the uniqueness of bipolar depression but fails to become operational. Recent data from randomized clinical trials of new anticonvulsants and second-generation antipsychotics should lead to the development of a modern definition of treatment-resistant bipolar depression, and specific therapeutic algorithms. Conclusion: We suggest a redefinition of resistant bipolar I and II depression. We propose different degrees of severity within bipolar depression in a stepwise manner.

引用

页码：429 / 440

页数：12