Tryptophan catabolism generates autoimmune-preventive regulatory T cells

被引：96
作者：
Fallarino, Francesca
Grohmann, Ursula
You, Sylvaine
McGrath, Barbara C.
Cavener, Douglas R.
Vacca, Carmine
Orabona, Ciriana
Bianchi, Roberta
Belladonna, Maria L.
Volpi, Claudia
Fioretti, Maria C.
Puccetti, Paolo
机构：
[1] Univ Perugia, Pharmacol Sect, Dept Expt Med, I-06126 Perugia, Italy
[2] Hop Necker Enfants Malad, INSERM, U580, IRNEM, F-75015 Paris, France
[3] Penn State Univ, Dept Biol, University Pk, PA 16802 USA
来源：
TRANSPLANT IMMUNOLOGY | 2006年 / 17卷 / 01期
关键词：
dendritic cells; regulatory T cells; tryptophan;
D O I：
10.1016/j.trim.2006.09.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4(+)CD25(-) cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：58 / 60
页数：3
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