New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

被引：30

作者：

Li, Peihai ^{[1
,2
,3
]}

Zhang, Mengqi ^{[1
,3
]}

Li, Haonan ^{[1
]}

Wang, Rongchun ^{[1
,3
]}

Hou, Hairong ^{[1
,3
]}

Li, Xiaobin ^{[1
,3
]}

Liu, Kechun ^{[1
,3
]}

Chen, Hao ^{[4
]}

机构：

[1] Qilu Univ Technol, Engn Res Ctr Zebrafish Models Human Dis & Drug Sc, Shandong Prov Engn Lab Biol Testing Technol, Shandong Acad Sci,Biol Inst, Jinan 250103, Peoples R China

[2] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Peoples R China

[3] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Key Lab Biosensor Shandong Prov, Jinan 250103, Peoples R China

[4] Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Bioact Subst, Qingdao 266061, Peoples R China

来源：

MARINE DRUGS | 2021年 / 19卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金; 中国博士后科学基金;

关键词：

marine-derived fungus; Aspergillus austroafricanus; novel bioactive metabolites; pro-angiogenesis; anti-inflammatory effects;

D O I：

10.3390/md19020098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one new pteridine alkaloid asperpteridinate A (3), with eleven known compounds (4-14). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds 2, 4, 5, 7, 10 exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds 7, 8, 10, 11 displayed anti-inflammatory activity in a CuSO4-induced zebrafish inflammation model, and compound 6 showed significant cytotoxicity against HepG2 cells with an IC50 value of 30 mu g/mL.

引用

页数：12

共 28 条

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