Highly stereoselective biocatalytic reduction of alpha-halo ketones

被引：12

作者：

Alanvert, Emmanuelle ^{[1
]}

Doherty, Claire ^{[1
]}

Moody, Thomas S. ^{[1
]}

Nesbit, Nicholena ^{[1
]}

Rowan, Andrew S. ^{[1
]}

Taylor, Stephen J. C. ^{[1
]}

Vaughan, Fatima ^{[1
]}

Vaughan, Tony ^{[1
]}

Wiffen, Jonathan ^{[1
]}

Wilson, Ian ^{[1
]}

机构：

[1] Almac Sci, Biocatalysis Grp, Craigavon BT63 5QD, North Ireland

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 21期

关键词：

CHIRAL ALCOHOLS; ETHYL; 4-CHLORO-3-OXOBUTANOATE; SACCHAROMYCES-CEREVISIAE; GLUCOSE-DEHYDROGENASE; ASYMMETRIC REDUCTION; LACTOBACILLUS-KEFIR; MICROBIAL REDUCTION; CARBONYL REDUCTASE; CANDIDA MAGNOLIAE; PROTEASE;

D O I：

10.1016/j.tetasy.2009.10.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The use of recombinant carbonyl reductase biocatalysts for the reduction of alpha-halo ketone intermediates to their corresponding alpha-halo alcohols has been investigated. The alpha-halo alcohol is obtained in good yield from the corresponding ketone in a stereoselective manner. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2462 / 2466

页数：5

共 28 条

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