Ixekizumab May Improve Renal Function in Psoriasis

被引：30
作者：
Amoruso, Giuseppe Fabrizio [1 ]
Nistico, Steven Paul [2 ]
Iannone, Luigi [2 ]
Russo, Emilio [2 ]
Rago, Giuseppe [3 ]
Patruno, Cataldo [2 ]
Bennardo, Luigi [2 ]
机构：
[1] Mariano Santo Hosp, Unit Dermatol, I-87100 Cosenza, Italy
[2] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Unit Dermatol, Viale Europa SNC, I-88100 Catanzaro, Italy
[3] Osped Rossano, COVID Pneumol Unit, I-87067 Rossano, Italy
来源：
HEALTHCARE | 2021年 / 9卷 / 05期
关键词：
ixekizumab; psoriasis; chronic renal failure; IL-17; IL-23;
D O I：
10.3390/healthcare9050543
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Background: Psoriasis is a chronic dermatological condition characterized by lesions on extensor surfaces, hands, feet, and genital areas. Chronic renal failure is often associated with metabolic syndrome and inflammatory conditions, such as psoriasis. Case report: In this paper, we report a patient with stage-three chronic renal failure that improved his renal condition after treatment with ixekizumab, an anti-IL17A drug used in the treatment of various cutaneous and rheumatological conditions. Conclusions: IL17A blockage may help to treat various autoimmune and inflammatory conditions, such as psoriasis, that may lead to renal impairment. Further investigation is necessary in order to prove the effectiveness of this drug in renal conditions.
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相关论文
共 28 条
[1]   Combination Therapy of Acarbose and Cyclosporine a Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice [J].
Chen, Hsin-Hua ;
Lin, Chi-Chien ;
Tung, Yu-Tang ;
Chao, Ya-Hsuan ;
Huang, Wen-Ching ;
Lee, Po-Ying .
MOLECULES, 2020, 25 (08)
[2]   A Rare Case of Drug-Induced Erectile Dysfunction with Secukinumab Solved After Switch to Ixekizumab in A Psoriatic Patient: A Case Report [J].
Dastoli, Stefano ;
Iannone, Luigi Francesco ;
Bennardo, Luigi ;
Silvestri, Martina ;
Palleria, Caterina ;
Nistico, Steven Paul ;
De Sarro, Giovambattista ;
Russo, Emilio .
CURRENT DRUG SAFETY, 2020, 15 (01) :69-72
[3]   Emerging role of anti-IL23 in the treatment of psoriasis: When humanized is very promising [J].
Dattola, Annunziata ;
Silvestri, Martina ;
Tamburi, Federica ;
Amoruso, Giuseppe F. ;
Bennardo, Luigi ;
Nistico, Steven P. .
DERMATOLOGIC THERAPY, 2020, 33 (06)
[4]   Update of calcineurin inhibitors to treat inverse psoriasis: A systematic review [J].
Dattola, Annunziata ;
Silvestri, Martina ;
Bennardo, Luigi ;
Del Duca, Ester ;
Longo, Caterina ;
Bianchi, Luca ;
Nistico, Steven .
DERMATOLOGIC THERAPY, 2018, 31 (06)
[5]   Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis [J].
Frantz, Travis ;
Wright, Ellen G. ;
Balogh, Esther A. ;
Cline, Abigail ;
Adler-Neal, Adrienne L. ;
Feldman, Steven R. .
CHILDREN-BASEL, 2019, 6 (11)
[6]   Biologics for the treatment of autoimmune renal diseases [J].
Holdsworth, Stephen R. ;
Gan, Poh-Yi ;
Kitching, A. Richard .
NATURE REVIEWS NEPHROLOGY, 2016, 12 (04) :217-231
[7]   Safety profile of biologic drugs for psoriasis in clinical practice: An Italian prospective pharmacovigilance study [J].
Iannone, Luigi Francesco ;
Bennardo, Luigi ;
Palleria, Caterina ;
Roberti, Roberta ;
De Sarro, Caterina ;
Naturale, Maria Diana ;
Dastoli, Stefano ;
Donato, Luca ;
Manti, Antonia ;
Valenti, Giancarlo ;
D'Amico, Domenico ;
D'Attola, Santo ;
De Francesco, Adele Emanuela ;
Bosco, Vincenzo ;
Di Paola, Eugenio Donato ;
Nistico, Steven Paul ;
Citraro, Rita ;
Russo, Emilio ;
De Sarro, Giovambattista .
PLOS ONE, 2020, 15 (11)
[8]   Risk Factors for the Development of Psoriasis [J].
Kamiya, Koji ;
Kishimoto, Megumi ;
Sugai, Junichi ;
Komine, Mayumi ;
Ohtsuki, Mamitaro .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (18)
[9]   Effect of anti-tumor necrosis factor alpha treatment of rheumatoid arthritis and chronic kidney disease [J].
Kim, Hyun Woo ;
Lee, Chang-Keun ;
Cha, Hoon-Suk ;
Choe, Jung-Yoon ;
Park, Eun-Jung ;
Kim, Jinseok .
RHEUMATOLOGY INTERNATIONAL, 2015, 35 (04) :727-734
[10]  
Koike Yuta, 2019, JAAD Case Rep, V5, P150, DOI 10.1016/j.jdcr.2018.11.016
123