Synthesis and antifungal activities of 5/6-arylamino-4,7-dioxobenzothiazoles

被引：38

作者：

Ryu, CK ^{[1
]}

Kang, HY

Ki, YJ

Shin, KH

Lee, BH

机构：

[1] Ewha Womans Univ, Coll Pharm, Seodaemun Ku, Seoul 120750, South Korea

[2] Wonkwang Univ, Coll Pharm, Iksan 570749, Chonbuk, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(00)00301-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5/6-Arylamino-4,7 -dioxobenzothiazoles were synthesized and tested for in vitro antifungal activities against pathogenic fungi. Most of the tested 4,7-dioxobenzothiazoles exhibited potent antifungal activities against Candida species and Aspergillus niger (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1589 / 1591

页数：3

共 13 条

[1]

Di Rigo J.-P., 1996, J BIOL CHEM, V271, P15341

[2] SYNTHESIS OF ALKYL-4,7-DIOXOBENZOTHIAZOLES WITH PROPHYLACTIC ANTIMALARIAL ACTIVITY [J].

FRIEDMAN, MD ;

STOTTER, PL ;

PORTER, TH ;

FOLKERS, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1314-1316

[3] HUMAN MYCOSES - DRUGS AND TARGETS FOR EMERGING PATHOGENS [J].

GEORGOPAPADAKOU, NH ;

WALSH, TJ .

SCIENCE, 1994, 264 (5157) :371-373

[4]

JESCHKE P, 1993, Patent No. 519290

[5] Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart [J].

Kim, H ;

Xia, D ;

Yu, CA ;

Xia, JZ ;

Kachurin, AM ;

Zhang, L ;

Yu, L ;

Deisenhofer, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8026-8033

[6]

MEGINNIS MR, 1996, ANTIBOTICS LAB MED, P176

[7] FEASIBILITY OF A HIGH-FLUX ANTICANCER DRUG SCREEN USING A DIVERSE PANEL OF CULTURED HUMAN TUMOR-CELL LINES [J].

MONKS, A ;

SCUDIERO, D ;

SKEHAN, P ;

SHOEMAKER, R ;

PAULL, K ;

VISTICA, D ;

HOSE, C ;

LANGLEY, J ;

CRONISE, P ;

VAIGROWOLFF, A ;

GRAYGOODRICH, M ;

CAMPBELL, H ;

MAYO, J ;

BOYD, M .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (11) :757-766

[8] Uncompetitive substrate inhibition and noncompetitive inhibition by 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT) and 2-n-Nonyl-4-hydroxyquinoline-N-oxide (NQNO) is observed for the cytochrome bo(3) complex: Implications for a Q(H-2)-loop proton translocation mechanism [J].

Musser, SM ;

Stowell, MHB ;

Lee, HK ;

Rumbley, JN ;

Chan, SI .

BIOCHEMISTRY, 1997, 36 (04) :894-902

[9] SITE OF INHIBITION OF MITOCHONDRIAL ELECTRON-TRANSFER BY COENZYME-Q ANALOGS [J].

ROBERTS, H ;

CHOO, WM ;

SMITH, SC ;

MARZUKI, S ;

LINNANE, AW ;

PORTER, TH ;

FOLKERS, K .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1978, 191 (01) :306-315

[10]

Ryu Chung-Kyu, 1994, Archives of Pharmacal Research (Seoul), V17, P139, DOI 10.1007/BF02974248

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