Is adherence therapy an effective adjunct treatment for patients with schizophrenia spectrum disorders? A systematic review and meta-analysis

被引：30

作者：

Gray, Richard ^{[1
,2
]}

Bressington, Daniel ^{[3
]}

Ivanecka, Ada ^{[4
]}

Hardy, Sheila ^{[5
,6
,7
]}

Jones, Martin ^{[8
]}

Schulz, Michael ^{[9
,10
]}

von Bormann, Suparpit ^{[11
]}

White, Jacquie ^{[12
]}

Anderson, Kathryn Hoehn ^{[13
]}

Chien, Wai-Tong ^{[3
]}

机构：

[1] Hamad Med Corp, Hlth Serv & Populat Res Ctr, Doha, Qatar

[2] Univ S Australia, Adelaide, SA 5001, Australia

[3] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China

[4] ADIGO, Bratislava, Slovakia

[5] Northamptonshire Healthcare NHS Fdn Trust, Kettering, Northants, England

[6] UCL, London, England

[7] Univ Northampton, Northampton, England

[8] Univ S Australia, Dept Rural Hlth, Whyalla Norrie, Australia

[9] Diacon Univ Appl Sci Bielefeld, Bielefeld, Germany

[10] Univ Halle Wittenberg, Fac Med, Inst Nursing & Healthcare, D-06108 Halle, Sachsen, Germany

[11] Boromarajonani Coll Nursing Changwat Nonthaburi, Res & Int Affairs, Nonthaburi, Thailand

[12] Univ Hull, Fac Hlth & Social Care, Learning Teaching & Qual, Kingston Upon Hull HU6 7RX, N Humberside, England

[13] Georgia Southern Univ Nursing, Ctr Nursing Scholarship & Res, Statesboro, GA USA

来源：

BMC PSYCHIATRY | 2016年 / 16卷

关键词：

Schizophrenia; Adherence therapy; Compliance; Adherence; Systematic review; Meta-analysis; Schizophrenia-spectrum disorders; RANDOMIZED CONTROLLED-TRIAL; IMPROVE MEDICATION ADHERENCE; RATING-SCALE; PEOPLE; RELIABILITY; VALIDITY; INSIGHT; PANSS;

D O I：

10.1186/s12888-016-0801-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Poor adherence to medication in schizophrenia spectrum disorders leads to inadequate symptom control. Adherence therapy (AT) is an intervention that seeks to reduce patients' psychiatric symptoms by enhancing treatment adherence. We aimed to systematically review the trial evidence of the effectiveness of AT on improving clinical outcomes in these patients. Method: Systematic review and meta-analysis of published RCTs. We included studies testing AT as an adjunct intervention against treatment as usual or a comparator intervention in the general adult psychiatric population. The primary outcome of interest was improvement in psychiatric symptoms. Results: We included six studies testing AT in schizophrenia spectrum disorders published since 2006. A meta-analysis showed AT significantly reduced psychiatric symptoms compared to usual treatment over a follow-up period of less than 1 year. We found no significant effects of AT on patients' adherence and adherence attitudes. Conclusions: AT is an effective adjunctive treatment for people with schizophrenia spectrum disorders. Prospero: CRD42015016779

引用

页数：12

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