Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression

被引：748
作者：
Huber, KM
Kayser, MS
Bear, MF [1 ]
机构：
[1] Brown Univ, Howard Hughes Med Inst, Providence, RI 02912 USA
[2] Brown Univ, Dept Neurosci, Providence, RI 02912 USA
来源：
SCIENCE | 2000年 / 288卷 / 5469期
关键词：
D O I：
10.1126/science.288.5469.1254
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, Local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.
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页码：1254 / 1256
页数：3
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