Challenges of antibacterial drug discovery

被引：8
作者：
Reck, Folkert [1 ]
Jansen, Johanna M. [1 ]
Moser, Heinz E. [1 ]
机构：
[1] Novartis Inst BioMed Res, 5300 Chiron Way, Emeryville, CA 94608 USA
来源：
ARKIVOC | 2019年
关键词：
Drug discovery; antibiotics; property space; safety; medicinal chemistry; PERMEABILITY; SOLUBILITY; ACTIVATION; CHEMISTRY; MECHANISM; TRENDS; AGENTS; BROAD;
D O I：
10.24820/ark.5550190.p010.955
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efforts to discover novel antibacterial drugs over the past decades have been characterized by high attrition rates, driven mainly by technical challenges, high dose and safety requirements, regulatory difficulties and low-cost generic competition, resulting in a broken financial model. Consequently, most pharmaceutical and biotech companies have exited their research efforts in this field, leaving the required rejuvenation of antibacterial drugs under-resourced. This article sheds light on some of the technical difficulties and offers thoughts and suggestions on how to address and overcome these. [GRAPHICS] .
引用
收藏
页码：227 / 244
页数：18
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