Pathophysiology of anorexia of aging

被引：2

作者：

Fetissov, Serguei O. ^{[1
]}

Petit, Andre ^{[1
]}

Dechelotte, Pierre ^{[1
]}

机构：

[1] Univ Rouen, CHU Rouen, UFR Med Pharm, Inst Rech Biomed,Lab Aden EA4311,IFR 23, F-76183 Rouen, France

来源：

NUTRITION CLINIQUE ET METABOLISME | 2009年 / 23卷 / 03期

关键词：

Food intake; Appetite; Nutrition; Geriatrics; Gut; Microflora; Neuropeptides; Hormones; Autoantibodies; HELICOBACTER-PYLORI INFECTION; BROWN-NORWAY RATS; PLASMA GHRELIN LEVELS; Y GENE-EXPRESSION; GROWTH-HORMONE; NEUROPEPTIDE-Y; FOOD-INTAKE; BACTERIAL-CONTAMINATION; EATING-DISORDERS; ELDERLY SUBJECTS;

D O I：

10.1016/j.nupar.2009.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A relative reduction in food intake in older versus younger individuals is commonly present in the general population and is often referred to as anorexia of aging. In most cases, anorexia of aging represents a normal physiological phenomenon, but sometimes it may underlie vulnerability for the frailty syndrome and increased mortality. However, the mechanisms responsible for anorexia of aging are not completely understood. In this review, we focused on the biological mechanisms which may trigger development in older subjects and experimental animals a resistance to anabolic and orexigenic peptide messengers including neuropeptide Y, ghrelin and growth hormone. The putative role of the aging gut, microbial intestinal contamination and the immune system are also discussed. (c) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：118 / 123

页数：6

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