Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein

被引：14

作者：

Kim, Sanghee

Sohn, Dae Won

Kim, Youn Chul

Kim, Soon-Ai

Lee, Sang Kook

Kim, Hak Sung

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, Jeonbuk, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 110460, South Korea

[3] Ewha Womans Univ, Seoul 120750, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2007年 / 30卷 / 01期

关键词：

baicalein; flavonoid; modified synthesis; improved synthetic route;

D O I：

10.1007/BF02977773

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A modified procedure of a previous synthetic route for baicalein was developed in order to obtain more than ten grams of baicalein for in vivo test. There were several difficulties in applying the published experimental procedures for a large scale of synthesis. The modified synthetic work was successfully accomplished by reducing amount of strong Lewis acid in Fries rearrangement and using tetrabutylammonium iodide as an additive to speed up the demethylation reaction in refluxing HBr into completion.

引用

页码：18 / 21

页数：4

共 16 条

[1] A CONCISE SYNTHESIS OF (-)-CONDURITOL-F FROM L-QUEBRACHITOL VIA ALCL3-NORMAL-BU4NI MEDIATED DEMETHYLATION [J].