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Grad Univ Adv Studies, Div Human Genet, Dept Integrated Genet, Natl Inst Genet,Res Org Informat & Syst, Mishima, Shizuoka 4118540, Japan Grad Univ Adv Studies, Div Human Genet, Dept Integrated Genet, Natl Inst Genet,Res Org Informat & Syst, Mishima, Shizuoka 4118540, Japan