Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia

被引:24
作者
Nagaraja, Nandakumar
Andrade, Chittaranjan [1 ]
Sudha, Suresh
Singh, Nagendra Madan
Chandra, J. Suresh
Venkataraman, B. V.
机构
[1] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India
[2] Natl Inst Mental Hlth & Neurosci, Cent Anim Res Facil, Bangalore 560029, Karnataka, India
[3] St Johns Med Coll, Dept Pharmacol, Bangalore 560034, Karnataka, India
关键词
electroconvulsive therapy; electroconvulsive shocks; mifepristone; cortisol; amnesia; memory; cognition; rats;
D O I
10.1007/s00213-006-0593-y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. Objectives Using mifepristone (a glucocorticoid receptor antagonist) as a chemical probe, we sought to examine steroid mechanisms in an animal model of ECT-induced retrograde amnesia. Materials and methods Adult, male Wistar rats (n=68) trained in a step-through passive-avoidance task were randomized to receive mifepristone (20 or 40 mg kg(-1) day(-1)) or vehicle (control). These treatments were administered 1 day before the electroconvulsive shock (ECS) course and, again, 1 h before each of five once-daily true (30 mC) or sham ECS. Recall of pre-ECS learning was tested 1 day after the last ECS. Results Relative to sham ECS, true ECS resulted in significant retrograde amnesia in the vehicle group but not in either of the mifepristone groups. In sham ECS-treated animals, mifepristone did not significantly influence recall. In ECS-treated rats, the higher but not the lower dose of mifepristone was associated with significant protection against the retrograde amnesia evident in the vehicle group. Conclusion Mifepristone administered before the ECT seizure may attenuate ECT-induced retrograde amnesia. This suggests that glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia.
引用
收藏
页码:73 / 80
页数:8
相关论文
共 40 条
  • [1] The antiglucocorticoid action of mifepristone
    Agarwal, MK
    [J]. PHARMACOLOGY & THERAPEUTICS, 1996, 70 (03) : 183 - 213
  • [2] Phenylephrine and ECS-induced retrograde amnesia
    Anand, A
    Andrade, C
    Sudha, S
    Guido, S
    Venkataraman, BV
    [J]. JOURNAL OF ECT, 2001, 17 (03) : 166 - 169
  • [3] Effect of stimulus intensity and number of treatments on ECS-related seizure duration and retrograde amnesia in rats
    Andrade, C
    Thyagarajan, S
    Vinod, PS
    Srikanth, SN
    Rao, NSK
    Chandra, JS
    [J]. JOURNAL OF ECT, 2002, 18 (04) : 197 - 202
  • [4] Effects of pulse amplitude, pulse frequency, and stimulus duration on seizure threshold: A laboratory investigation
    Andrade, C
    Kurinji, S
    Sudha, S
    Chandra, JS
    [J]. JOURNAL OF ECT, 2002, 18 (03) : 144 - 148
  • [5] ANDRADE C, 2005, HDB PSYCHIAT S ASIAN, P553
  • [6] ANDRADE C, 1992, P NAT WORKSH ECT PRI, P107
  • [7] [Anonymous], 1988, ELECTROCONVULSIVE TH
  • [8] EFFECTS OF ELECTROCONVULSIVE-THERAPY ON NEUROPSYCHOLOGICAL FUNCTION AND CIRCULATING LEVELS OF ACTH, CORTISOL, PROLACTIN, AND TSH IN PATIENTS WITH MAJOR DEPRESSIVE-ILLNESS
    APERIA, B
    BERGMAN, H
    ENGELBREKTSON, K
    THOREN, M
    WETTERBERG, L
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 1985, 72 (06) : 536 - 541
  • [9] An open label trial of C-1073 (mifepristone) for psychotic major depression
    Belanoff, JK
    Rothschild, AJ
    Cassidy, F
    DeBattista, C
    Baulieu, EE
    Schold, C
    Schatzberg, AF
    [J]. BIOLOGICAL PSYCHIATRY, 2002, 52 (05) : 386 - 392
  • [10] Influence of sexual hormone antagonists on the anticonvulsant action of conventional antiepileptic drugs against electrically- and pentylenetetrazol-induced seizures in mice
    Borowicz, KK
    Luszczki, J
    Swiader, M
    Kleinrok, Z
    Czuczwar, SJ
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2004, 14 (01) : 77 - 85