Effect of alpha-2 adrenoceptor antagonists on colonic function in rats

被引：2
|
作者：
Yamamoto, O [1 ]
Niida, H [1 ]
Tajima, K [1 ]
Tanaka, M [1 ]
Makita, Y [1 ]
Ueda, F [1 ]
Yano, J [1 ]
机构：
[1] Nippon Shinyaku Co Ltd, Discovery Res Labs, Minami Ku, Kyoto 6018550, Japan
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2000年 / 12卷 / 03期
关键词：
5-hydroxytryptamine; alpha-2 adrenoceptor antagonists; bethanechol; castor oil; faecal excretion; water-avoidance stress;
D O I：
10.1046/j.1365-2982.2000.00206.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We studied the effect of alpha-2 adrenoceptor antagonists on colonic function stimulated by water-avoidance stress, 5-hydroxytryptamine (5-HT), bethanechol and castor oil by comparison with the effects of atropine and a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, ondansetron. Yohimbine, idazoxan and atropine, but not ondansetron, significantly inhibited water-avoidance stress-stimulated faecal excretion. Yohimbine and idazoxan inhibited neither 5-HT- nor bethanechol-stimulated faecal excretion. In contrast, atropine inhibited both 5-HT- and bethanechol-stimulated faecal excretion and ondansetron inhibited 5-HT-stimulated faecal excretion. Yohimbine did not inhibit the incidence of diarrhoea induced by castor oil, but idazoxan significantly inhibited diarrhoea observed during a 1-h period after the administration of castor oil. Both atropine and ondansetron inhibited diarrhoea during a 2-h period after the administration of castor oil. These findings suggest that alpha-2 adrenoceptor antagonists specifically inhibit colonic motor function stimulated by stress in rats.
引用
收藏
页码：249 / 255
页数：7
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