Copper-Promoted Thiolation of C(sp2)-H Bonds Using a 2-Amino Alkylbenzimidazole Directing Group

被引：38

作者：

Liu, Shuang-Liang ^{[1
]}

Li, Xue-Hong ^{[1
]}

Shi, Tan-Hao ^{[1
]}

Yang, Guang-Chao ^{[1
]}

Wang, Hai-Li ^{[1
]}

Gong, Jun-Fang ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450001, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Nitrogen heterocycles; Copper; C-H activation; Directing groups; Sulfur; C-H BONDS; CATALYZED SULFENYLATION; FUNCTIONALIZATIONS; ARYL; DISULFIDES; THIOLS; ACTIVATION; INHIBITORS; THIOETHERS; COMPLEXES;

D O I：

10.1002/ejoc.201700147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-promoted thiolation of C(sp(2))-H bonds with disulfides was achieved by using 2-amino alkylbenzimidazole (MBIP amine) as a new and removable N,N-bidentate directing group. This strategy gives a variety of functionalized thioethers in moderate to excellent yields in a simple and efficient way. Importantly, the substrate scope is not limited to aromatic amides; diverse alkenyl amides are also compatible. Furthermore, this synthetic approach provides a potentially feasible way to achieve structural modification of related benzimidazole-containing compounds through direct C-H activation.

引用

页码：2280 / 2289

页数：10

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