Jucara (Euterpe edulis Mart.) Supplementation Reduces Aberrant Crypt Foci and Increases SOD1 Expression in the Colorectal Mucosa of Carcinogenesis-Induced Rats

被引：12

作者：

dos Reis, Schalana Oliveira ^{[1
]}

da Luz, Tamires Conceicao ^{[1
]}

Monteiro da Silva Couto, Cinthia Vidal ^{[1
]}

Dalbo, Juliana ^{[1
]}

Nunes, Louisiane de Carvalho ^{[1
]}

Martins, Marina Carvalho ^{[1
]}

Silva, Pollyanna Ibrahim ^{[1
]}

Alvares da Silva, Adriana Madeira ^{[1
]}

Trivilin, Leonardo Oliveira ^{[1
]}

机构：

[1] Univ Fed Espirito Santo, Alto Univ S-N, BR-29500000 Guararema, Alegre, Brazil

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2020年 / 72卷 / 04期

关键词：

OXIDATIVE STRESS; ANTIOXIDANT CAPACITY; CHEMICAL-COMPOSITION; CANCER; DIETARY; POLYPHENOLS; BIOMARKERS; MICROBIOTA; FRUITS; RISK;

D O I：

10.1080/01635581.2019.1649437

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antioxidants present in food can act as a protective factor against the development of colorectal cancer (CRC) by reducing the development of aberrant crypt foci (ACF). This study aimed to analyze the effects of supplementation with jucara fruit pulp on the number of ACF and the SOD1 expression in an experimental model of CRC. Colorectal carcinogenesis was induced with 1,2-dimethylhydrazine (DMH) in 16 young female rats (Rattus norvegicus) given a diet supplemented with either jucara fruit pulp (DMH+/jucara+) or control (DMH+/jucara-). Five animals were used as a negative control (DMH-/jucara-). The (DMH+/jucara+) group received 14 days of supplementation (100 ml/animal/day) at 2-day intervals for 1 month. The number of ACF, area of positive staining for SOD1, and SOD1 expression score were evaluated. The (DMH+/jucara+) group presented a lower number of ACF, ACF > 3 crypts, and greater SOD1 expression in the colorectal mucosa. Based on the reduction in the number of lesions and possible positive impact on antioxidant enzymes, jucara fruit pulp appears to support the prevention of CRC, opening new possibilities for its use in dietary supplementation, as well as in the development of products and medications for the prevention and treatment of CRC.

引用

页码：610 / 619

页数：10