Two new lignans from the fruits of Forsythia suspensa

被引：8

作者：

Cao, Jun ^{[1
,2
]}

Shao, Si-Yuan ^{[1
,2
]}

Zhang, Xu ^{[1
,2
]}

Yuan, Xiang ^{[1
,2
]}

Feng, Zi-Ming ^{[1
,2
]}

Jiang, Jian-Shuang ^{[1
,2
]}

Yang, Ya-Nan ^{[1
,2
]}

Zhang, Pei-Cheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Oleaceae; Forsythia suspensa; sesquinorlignan; PHENYLETHANOID GLYCOSIDES; EXTRACT;

D O I：

10.1080/10286020.2019.1666828

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new lignans, wikstronoside B (1) and forsysesquinorlignan (2), were isolated from the fruits of Forsythia suspensa, along with two known sesquineolignans, hedyotol A and hedyotol C (3 and 4). The structures of new compounds were established via extensive spectroscopy techniques, including UV, IR, HRESIMS, NMR, and ECD. Compounds 3 and 4 were isolated from this plant for the first time. Their anti-inflammatory effects were evaluated via a detection model with LPS-induced murine macrophage RAW264.7 cells, and compound 3 showed a moderate activity.

引用

页码：418 / 424

页数：7

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