Treatable traits in acute exacerbations of chronic airway diseases

被引:55
作者
McDonald, Vanessa M. [1 ,2 ,3 ]
Osadnik, Christian R. [4 ,5 ]
Gibson, Peter G. [1 ,2 ,3 ]
机构
[1] Univ Newcastle, Fac Hlth & Med, Prior Res Ctr Hlth Lungs, Level 2 West Wing,1 Kookaburra Circuit, New Lambton Hts, NSW 2305, Australia
[2] Univ Newcastle, Fac Hlth & Med, Ctr Excellence Severe Asthma, Level 2 West Wing,1 Kookaburra Circuit, New Lambton Hts, NSW 2305, Australia
[3] John Hunter Hosp, Dept Resp & Sleep Med, Newcastle, NSW, Australia
[4] Monash Univ, Dept Physiotherapy, Melbourne, Vic, Australia
[5] Monash Hlth, Monash Lung & Sleep, Melbourne, Vic, Australia
关键词
Acute exacerbations; chronic airway disease; asthma; COPD; bronchiectasis; treatable traits; OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION DECLINE; EXHALED NITRIC-OXIDE; PHYSICAL-ACTIVITY; MULTIDIMENSIONAL ASSESSMENT; BACTERIAL-INFECTIONS; ASTHMA EXACERBATIONS; CLINICAL MANAGEMENT; HOSPITAL ADMISSION; PRECISION MEDICINE;
D O I
10.1177/1479973119867954
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Acute exacerbations of chronic airway disease are common occurrences that cause a major burden of illness. Acute exacerbations are associated with impaired health status, increased lung function decline, hospitalization and increased risk of death. Exacerbation avoidance is a major priority. Despite this goal, exacerbations continue to occur and the need for effective models of care that optimize patient outcomes are urgently needed. 'Treatable Traits' is an approach to personalized medicine that has been proposed for the management of airway diseases. The treatable traits approach allows for the recognition of clinically important, identifiable and treatable disease characteristics, followed by targeted and individualized treatment interventions to address each trait. We review the literature relating to treatable traits in airway diseases; in particular, those traits that can predict exacerbations and approaches to management that aim to prevent exacerbations by using a treatable traits model of care. We propose this approach as a potentially useful model of care to both prevent and manage acute exacerbations.
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收藏
页数:16
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