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Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer
被引：16
作者：
Yi, Yu-Chiao
[2
,3
]
Chen, Mu-Kuan
[4
,5
]
Chen, Ling-Yun
[3
]
Ho, Esther Shih-Chu
[2
,6
]
Ying, Tsung-Ho
[1
,7
]
Wang, Po-Hui
[1
,7
]
Yang, Shun-Fa
[8
,9
,10
]
机构：
[1] Chung Shan Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[2] Taichung Vet Gen Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[3] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung, Taiwan
[4] Changhua Christian Hosp, Dept Otorhinolaryngol Head & Neck Surg, Changhua, Taiwan
[5] Mingdao Univ, Changhua, Taiwan
[6] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[7] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[8] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[9] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[10] Chung Shan Med Univ Hosp, Dept Clin Lab, Taichung, Taiwan
关键词：
Endometrial cancer;
Tissue inhibitors of metalloproteinases;
Polymorphism;
MATRIX METALLOPROTEINASE-2;
GROWTH-FACTOR;
BREAST CARCINOMAS;
GASTRIC-CANCER;
MELANOMA-CELLS;
MESSENGER-RNA;
EXPRESSION;
TIMP-1;
POPULATION;
APOPTOSIS;
D O I：
10.1016/j.cca.2009.09.015
中图分类号：
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities involved in tumorgenesis and mRNA expression of TIMP family members has been shown to be upregulated in numerous cancers and correlates with clinical outcomes. We investigated the association of TIMP-1 and TIMP-2 gene polymorphism with risk of endometrial cancer. Methods: In the present case-control study, we enrolled a total of 118 endometrial cancer patients confirmed by histopathology and 229 unrelated healthy individuals. Polymorphism for TIMP-1 (_372C>T) and TIMP-2 (_418G>C and _303C>T) genes was genotyped by PCR-RFLP. Results: Frequency of TIMP-1_372C/C genotype and 372-C allele differed significantly between patients with endometrial cancer (38.1% and 56.4% respectively) and healthy individuals (22.7% and 44.1% respectively). Individuals with TIMP-1_372 C/C genotype were at higher risk of endometrial cancer (OR = 2.37; 95%CI: 1.33-4.22). Stratification analysis showed that individuals with TIMP-1_372 C/C genotype were at increased risk for endometrioid (OR = 2.46; 95%CI 1.34-4.53) and low stage (stages I-II) endometrial cancer (OR = 3.24; 95%CI 1.22-4.13). However, no significant differences in TIMP-2_418G>C and TIMP-2_303C>T genotypes were observed between endometrial carcinoma cases and controls. Conclusion: Individuals with TIMP-1_372C/C genotype were at significantly higher risk of endometrial cancer. (C) 2009 Elsevier B.V. All rights reserved.
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页码：127 / 131
页数：5
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