Cognitive Behavior Therapy for Anxiety in Parkinson's Disease: Outcomes for Patients and Caregivers

Objective: Anxiety negatively impacts the quality of life of Parkinson's disease (PD) patients and caregivers. Despite high prevalence, there is a paucity of trials investigating effective treatments for anxiety in PD. This uncontrolled study investigated the use of a manualized and tailored Cognitive Behavior Therapy (CBT) for anxiety in PD.Methods: Participants completed 6 weekly CBT sessions. Pre-, post- and follow-up (3 and 6months) assessments were made. Change in outcomes were analysed using t-tests and Reliability Change Index. Of 17 PD patients who agreed to CBT, 12 completed the intervention.Results: This study showed a significant reduction in Hamilton Anxiety Rating Scale scores in PD immediately post CBT (t(11)=3.59, p<.01), maintained at 3-month (t(8)=2.83, p=.02) and 6-month (t(7)=2.07, p=.04) follow-up. A reduction in caregiver burden (t(11)=2.68, p=.03) was observed post intervention. Improvements in motor disability (t(11)=2.41, p=.04) and cognitive scores (t(11)=-2.92, p=.01) were also observed post intervention and at follow-up.Conclusions: Tailored CBT can be used to treat anxiety in PD.Clinical Implications: This study provides preliminary evidence suggesting that tailored CBT reduces anxiety in PD with persisting benefits, and lowers caregiver burden.