A Neural Network Critical for Spelling

被引：31

作者：

Cloutman, Lauren ^{[1
]}

Gingis, Leila ^{[1
]}

Newhart, Melissa ^{[1
]}

Davis, Cameron ^{[1
]}

Heidler-Gary, Jennifer ^{[1
]}

Crinion, Jennifer ^{[2
]}

Hillis, Argye E. ^{[1
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] UCL, Inst Cognit Neurosci, London, England

[3] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA

[4] Johns Hopkins Univ, Dept Cognit Neurosci, Baltimore, MD USA

来源：

ANNALS OF NEUROLOGY | 2009年 / 66卷 / 02期

关键词：

GRAPHEMIC BUFFER; ACQUIRED DYSGRAPHIA; MECHANISMS;

D O I：

10.1002/ana.21693

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We aimed to identify neuroanatomical regions associated with deficits to the graphemic buffer, a working memory component of the spelling system that holds the sequence of letter identities during production. We evaluated 331 patients with left hemisphere ischemic stroke with various spelling tests and magnetic resonance diffusion-weighted imaging and perfusion-weighted. imaging, within 48 hours of stroke onset. A voxel-wise statistical map showed that ischemia in voxels in posterior and inferior frontal and parietal cortex, subcortical white matter underlying prefrontal cortex, lateral occipital gyrus, or caudate was associated with impairment in maintaining the sequence of letter identities while spelling.

引用

页码：249 / 253

页数：5

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