Oncogene-induced senescence pathways weave an intricate tapestry

被引：111
作者：
Yaswen, Paul
Campisi, Judith
机构：
[1] Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
[2] Buck Inst Age Res, Novato, CA 94945 USA
来源：
CELL | 2007年 / 128卷 / 02期
关键词：
D O I：
10.1016/j.cell.2007.01.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, Sun et al. (2007) identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.
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收藏
页码：233 / 234
页数：2
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