Electro-oxidation and determination of gabapentin at gold electrode

被引：94
作者：
Hegde, Rajesh N. [1 ]
Swamy, B. E. Kumara [2 ]
Shetti, Nagaraj P. [1 ]
Nandibewoor, Sharanappa T. [1 ]
机构：
[1] Karnatak Univ, PG Dept Studies Chem, Dharwad 580003, Karnataka, India
[2] Kuvempu Univ, Dept Ind Chem, Jnana Sahyadri 577451, Shankaraghatta, India
来源：
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2009年 / 635卷 / 01期
关键词：
Gabapentin; Voltammetry; Gold electrode; Drug analysis; Oxidation; AQUEOUS ALKALINE-MEDIUM; ELECTROCHEMICAL OXIDATION; CARBON-PASTE; NEURONTIN; VOLTAMMETRY; PLASMA; SENSOR; SERUM; ACID;
D O I：
10.1016/j.jelechem.2009.08.004
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The electrochemical oxidation of gabapentin has been investigated for the first time by cyclic, linear sweep and differential-pulse voltammetry at different pH at gold electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentrations of gabapentin. The effect of surfactants was studied. The anodic peak was characterized and process was adsorption-controlled. The oxidation peak corresponds to the amine and probable mechanism was proposed. According to the linear relation between the peak current and the gabapentin concentration, differential-pulse voltammetric method for the quantitative determination in pharmaceuticals was developed. The linear response was obtained in the range of 0.3-15 mu M with a detection limit of 0.13 mu M with good selectivity and sensitivity. The proposed method was successfully applied to gabapentin determination in pharmaceutical samples and for the detection of gabapentin in urine as a real sample. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：51 / 57
页数：7
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