Effects of D-amphetamine on extracellular dopamine content and generation of hydroxyl radicals in the striatum of freely moving rats

被引：1
|
作者：
Andyarzhanova, EA [1 ]
Afanas'ev, II [1 ]
Kudrin, VS [1 ]
Raevskii, KS [1 ]
机构：
[1] Russian Acad Med Sci, Inst Pharmacol, Lab Neurochem Pharmacol, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 11期
关键词：
D-amphetamine; dopamine; hydroxyl radicals; intracerebral microdialysis;
D O I：
10.1007/BF02433418
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Four intraperitoneal injections of D-amphetamine induced dose-dependent effects on extracellular dopamine content and generation of hydroxyl radical in rat striatum. Neurotoxic effects of D-amphetamine were probably mediated by intense generation of hydroxyl radicals.
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页码：1125 / 1127
页数：3
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